Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus
Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus
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DOI：
10.1016/j.vetpar.2004.10.019
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发表时间：
2005-03-10
影响因子：
2.6
通讯作者：
Lyndal-Murphy, A
中科院分区：
文献类型：
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作者：
Le Jambre, L;Geoghegan, J;Lyndal-Murphy, A
绵羊胃肠道寄生虫对莫西菌素耐药性（moxidectin resistance, MOX-R）的发展已经对其他驱虫类群产生了多重耐药性，这使得控制这些菌株变得非常困难。本研究对毛线虫和弯血蜱的MOX-R菌株的抗虫模式进行了分析，以了解抗虫药在控制这两种菌株中的剩余作用。两属的纯合子MOX-R个体对莫西菌素没有影响。对于MOX- r杂合子，口服200 μ g/kg阿维菌素（ABA）可去除25%的弯纹丝虫病，而口服200 μ g/kg阿维菌素可减少72%的弯纹丝虫病。将ABA的剂量率提高一倍，平均疗效达到37%。因此，在扭曲鼠中，两种驱虫动物的优势程度明显不同。以8mg/kg左旋咪唑和185 mg/kg萘酞磷的剂量率对MOX-R纯合子弯纹丝虫虫数的减少率为95%左右，但对MOX-R纯合子红叶丝虫虫数的减少率分别为85%和7%。(c) 2004 Elsevier B.V.版权所有
The development of moxidectin resistance (MOX-R) in sheep parasitic gastrointestinal nematodes already carrying multiple resistances to other anthelmintic groups has made control of these strains very difficult. The anthelmintic resistance patterns of MOX-R strains of Trichostrongylus colubriformis and Haemonchus contortus were characterized to provide an insight into the remaining role of anthelmintics in the control of such strains. Homozygous MOX-R individuals of both genera were unaffected by moxidectin. For MOX-R heterozygotes a dose rate of 200 mu g/kg abamectin (ABA) given orally removed 25% of H. contortus while 200 mu g/kg MOX given orally achieved a 72% reduction. Doubling the dose rate of ABA improved the mean efficacy to 37%. Consequently, in H. contortus, the degree of dominance differs markedly between the two anthelmintics. A dose rate of 8mg/kg levamisole and 185 mg/kg napthalophos achieved > 95% reduction in worm count of the MOX-R homozygous H. contortus but only 85 and 7%, respectively against the MOX-R homozygous T colubriformis. (c) 2004 Elsevier B.V. All rights reserved.