TELOMERE-LED PREMEIOTIC CHROMOSOME MOVEMENT IN FISSION YEAST
TELOMERE-LED PREMEIOTIC CHROMOSOME MOVEMENT IN FISSION YEAST
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DOI：
10.1126/science.8146661
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发表时间：
1994-04-08
期刊：
影响因子：
56.9
通讯作者：
HIRAOKA, Y
中科院分区：
文献类型：
--
作者：
CHIKASHIGE, Y;DING, DQ;HIRAOKA, Y
用荧光显微镜观察到分裂酵母活细胞减数分裂前的染色体运动。进一步的原位杂交分析表明，与着丝粒引导的有丝分裂染色体运动不同，端粒仍然聚集在减数分裂前染色体运动的前端。然而，一旦减数分裂染色体分离开始，着丝粒就恢复了染色体运动的主导地位，就像它们在有丝分裂中所做的那样。虽然以前没有观察到端粒的运动，但端粒的聚集使人想起高等真核生物中观察到的减数分裂前期染色体的花束结构，这表明端粒在真核生物中通常具有减数分裂前染色体事件所需的特定功能。
The movement of chromosomes that precedes meiosis was observed in living cells of fission yeast by fluorescence microscopy. Further analysis by in situ hybridization revealed that the telomeres remain clustered at the leading end of premeiotic chromosome movement, unlike mitotic chromosome movement in which the centromere leads. Once meiotic chromosome segregation starts, however, centromeres resume the leading position in chromosome movement, as they do in mitosis. Although the movement of the telomere first has not been observed before, the clustering of telomeres is reminiscent of the bouquet structure of meiotic-prophase chromosomes observed in higher eukaryotes, which suggests that telomeres perform specific functions required for premeiotic chromosomal events generally in eukaryotes.