Depression in multiple sclerosis: Relationship to working memory capacity
Depression in multiple sclerosis: Relationship to working memory capacity
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DOI：
10.1037/0894-4105.13.4.546
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发表时间：
1999-10-01
期刊：
影响因子：
2.4
通讯作者：
Tippin, JM
中科院分区：
文献类型：
--
作者：
Arnett, PA;Higginson, CI;Tippin, JM
最近的研究表明，多发性硬化症（MS）的抑郁症与认知要求任务的缺陷有关。对这种关系的一种解释是，抑郁的多发性硬化症患者的工作记忆能力可能会下降。本研究旨在验证这一假设。在一项工作记忆容量（阅读广度）任务和一项不影响工作记忆容量（单词广度）的短期记忆任务上，将抑郁的多发性硬化症患者与非抑郁的多发性硬化症患者和非抑郁的健康对照进行比较。支持能力降低模型，与非抑郁组相比，抑郁MS患者在阅读广度上的表现明显差（p < 0.001），但在单词广度上没有。此外，阅读广度与先前报道中显示的抑郁MS患者的能力要求任务显著相关。结果表明，抑郁症MS患者的工作记忆容量有限，工作记忆系统的中央执行部分可能受到最大的影响。
Recent research has shown that depression in multiple sclerosis (MS) is associated with deficits on cognitively demanding tasks. One explanation for this relationship is that depressed MS patients may have reduced working memory capacity. The present study was designed to test this hypothesis. Depressed MS patients were compared with nondepressed MS patients and nondepressed healthy controls on a task of working memory capacity (reading span) and a short-term memory task not taxing working memory capacity (word span). In support of the capacity-reduction model, compared with the nondepressed groups, depressed MS patients performed significantly worse on reading span (p < .001) but not on word span. Additionally, reading span was significantly correlated with capacity-demanding tasks shown to be impaired in depressed MS patients in previous reports. Results suggest that depressed MS patients are characterized by limited working memory capacity and that the central executive component of the working memory system may be most affected.