Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion
Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion
复制标题
DOI：
10.1080/10428190500235611
复制
发表时间：
2005-11-01
影响因子：
2.6
通讯作者：
Hernalsteen, D
中科院分区：
文献类型：
--
作者：
Bauwens, D;Hantson, P;Hernalsteen, D
我们报告一例在复发性淋巴瘤的清髓性化疗后接受了两次二甲基亚砜（DMSO）冷冻保存的自体外周血祖细胞（PBPCs）输注的患者病例。一名49岁男性在每次输注开始后的几分钟内出现一次强直 - 阵挛发作，并且在第二次输注后出现了严重且持续但可逆的脑病伴昏迷。患者的神经状况与电生理检查结果（脑电图和多模式诱发电位）密切相关，并且在较小程度上与放射学异常（磁共振成像）相关。使用DMSO冷冻保存的PBPCs输注可能会发生严重但可逆的神经并发症。
We report the case of a patient who received two infusions of dimethylsulfoxide ( DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma. A 49-year-old man presented an episode of tonic-clonic seizure over a few minutes after the start of each infusion and developed a profound and sustained but reversible encephalopathy with coma after the second infusion. The patient's neurological condition correlated well with the electrophysiological findings ( electroencephalogram and multimodality evoked potentials) and, to a lesser extent, with the radiological abnormalities ( magnetic resonance imaging). Severe but reversible neurological complications may occur with the infusion of PBPCs cryopreserved with DMSO.