Anemia in dialysis: its relation to acquired cystic kidney disease and serum levels of erythropoietin.
Anemia in dialysis: its relation to acquired cystic kidney disease and serum levels of erythropoietin.
复制标题
透析贫血：与获得性囊性肾病和促红细胞生成素血清水平的关系。
DOI：
10.1159/000168265
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发表时间：
1991
影响因子：
4.2
通讯作者：
L. Palop
中科院分区：
文献类型：
--
作者：
A. Fernández;L. Hortal;J. C. Rodríguez;N. Vega;C. Plaza;L. Palop
获得性囊性肾病与透析患者贫血的改善有关。有人认为这可能是由于囊肿产生促红细胞生成素。我们研究了110例患者，58例血液透析，52例持续动态腹膜透析，年龄48.6 +/- 14.78岁，透析时间44.5 +/- 35.53个月。每位患者均行肾脏超声检查，评估囊肿的存在和数量。这些发现与血液中血红蛋白、铁蛋白和促红细胞生成素的水平以及研究期间规定的输血次数有关。血液透析组血清促红细胞生成素水平为18.23 +/- 12.14 U/l，连续非卧床腹膜透析组为15.04 +/- 12.35 U/l，对照组为12.4 +/- 4.7 U/l。多囊肾病患者血红蛋白和促红细胞生成素明显增高。无囊肿患者的血红蛋白和促红细胞生成素水平最低，但双侧多发囊肿患者和1-3个孤立囊肿患者的血红蛋白和促红细胞生成素水平无显著差异。
Acquired cystic kidney disease has been related to improvement of anemia in dialysis patients. It has been suggested that this could be due to erythropoietin production by the cysts. We studied 110 patients, 58 on hemodialysis and 52 on continuous ambulatory peritoneal dialysis, with an age of 48.6 +/- 14.78 years and a time on dialysis of 44.5 +/- 35.53 months. A renal echography was performed in every patient, evaluating presence and number of cysts. These findings were related to the blood levels of hemoglobin, ferritin, and erythropoietin as well as to the number of transfusions prescribed during the year of the study. The serum erythropoietin level was 18.23 +/- 12.14 U/l in hemodialysis patients, 15.04 +/- 12.35 in patients on continuous ambulatory peritoneal dialysis, and 12.4 +/- 4.7 U/l in the control group. Hemoglobin and erythropoietin were significantly higher in patients with polycystic kidney disease. Patients without cysts had the lowest levels of hemoglobin and erythropoietin, although no significant difference was found in those with multiple bilateral cysts or in those with 1-3 isolated cysts.