Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men.
Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men.
复制标题
克隆相关的毒力结核分枝杆菌的复杂传播动力学与主要由人类免疫缺陷病毒阳性男同性恋者跳酒吧有关。
DOI：
10.1086/314991
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Musser,JM
中科院分区：
文献类型：
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作者：
Yaganehdoost,A;Graviss,EA;Ross,MW;Adams,GJ;Ramaswamy,S;Wanger,A;Frothingham,R;Soini,H;Musser,JM
Limited data suggest that measures to reduce tuberculosis transmission should be based on locations rather than on personal contacts. Molecular epidemiologic methods (analysis ofIS6110patterns, spoligotypes, variable numbers of tandem DNA repeats, and automated DNA sequence data) identified a cohort of 48 persons who were infected with progeny of the sameMycobacterium tuberculosisstrain. Epidemiologic investigation documented that a large proportion of the patients were gay white human immunodeficiency virus-positive men. Most practiced barhopping, an activity that involved patronizing many bars in the same neighborhood each night. Few subjects were directly linked to more than 1 or 2 other persons by conventional investigation methods, which shows that the transmission dynamics were unusually complex compared with most previously described episodes of strain spread. The data support the concept that identification of locations where pathogen dissemination likely occurs may provide additional strategies for targeted tuberculosis control.
