Lower CSF oxytocin concentrations in women with a history of childhood abuse
Lower CSF oxytocin concentrations in women with a history of childhood abuse
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DOI：
10.1038/mp.2008.112
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发表时间：
2009-10-01
影响因子：
11
通讯作者：
Nemeroff, C. B.
中科院分区：
文献类型：
--
作者：
Heim, C.;Young, L. J.;Nemeroff, C. B.
早年父母与子女关系的破裂，例如以虐待、忽视或丧失的形式，大大增加了成年后患精神病和某些医学疾病的风险。神经肽催产素（OT）在调节社会关系、依恋、社会支持、母性行为和信任以及防止压力和焦虑方面起着重要作用。因此，我们研究了成年女性早期生活逆境后中枢神经系统OT活性。我们测量了收集自22名年龄在18-45岁之间的医学健康女性的脑脊液（CSF）中的OT浓度，这些女性被分为非轻度与中度至重度暴露于各种形式的儿童虐待或忽视的女性。暴露于虐待与CSF OT浓度降低相关。一个特别强大的影响被确定为精神虐待。CSF OT浓度与暴露类别的数量、滥用的严重程度和持续时间以及当前焦虑等级之间存在负相关。如果复制，成人脑脊液OT水平较低与儿童创伤的关联可能表明，中枢OT功能的改变可能参与了儿童逆境的不良后果。分子精神病学（2009）14，954-958; doi：10.1038/mp.2008.112;在线发表2008年10月28日
Early-life disruption of the parent-child relationship, for example, in the form of abuse, neglect or loss, dramatically increases risk for psychiatric, as well as certain medical, disorders in adulthood. The neuropeptide oxytocin (OT) plays a seminal role in mediating social affiliation, attachment, social support, maternal behavior and trust, as well as protection against stress and anxiety. We therefore examined central nervous system OT activity after early-life adversity in adult women. We measured OT concentrations in cerebrospinal fluid (CSF) collected from 22 medically healthy women, aged 18-45 years, categorized into those with none-mild versus those with moderate-severe exposure to various forms of childhood abuse or neglect. Exposure to maltreatment was associated with decreased CSF OT concentrations. A particularly strong effect was identified for emotional abuse. There were inverse associations between CSF OT concentrations and the number of exposure categories, the severity and duration of the abuse and current anxiety ratings. If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity. Molecular Psychiatry (2009) 14, 954-958; doi:10.1038/mp.2008.112; published online 28 October 2008