Efficacy of a physical therapy program in patients with Parkinson's disease: A randomized controlled trial
Efficacy of a physical therapy program in patients with Parkinson's disease: A randomized controlled trial
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DOI：
10.1016/j.apmr.2004.08.008
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发表时间：
2005-04-01
影响因子：
4.3
通讯作者：
Wagenaar, RC
中科院分区：
文献类型：
--
作者：
Ellis, T;de Goede, CJ;Wagenaar, RC
目的：调查物理治疗 (PT) 计划对帕金森病 (PD) 患者的效果。设计：采用交叉设计的随机对照试验。地点：分别位于波士顿和阿姆斯特丹的两家门诊康复诊所。 参与者： 68 名被诊断为典型特发性 PD、Hoehn 和 Yahr II 期或 III 期且药物使用稳定的受试者。 干预：A 组在前 6 周接受 PT 和药物治疗 (MT)，随后仅在后 6 周接受 MT。 B 组在前 6 周仅接受 MT，后 6 周仅接受 PT 和 MT。主要结果指标：疾病影响概况 (SIP-68)、SIP-68 的活动能力部分、统一帕金森病评定量表 (UPDRS) 以及基线、6 周、12 周和 3 个月随访时的舒适步行速度 (CWS)。结果：第 6 周时，两组之间的差异各组对于 SIP 流动性（P = .015；效应大小 [ES] = .55）、CWS（P = .012；ES = .49）、UPDRS 的日常生活活动（ADL）部分（P = .014；ES = .45）和总 UPDRS（P = .007；ES = .56）具有显着性。总 SIP 以及 UPDRS 的精神状态和运动部分在各组之间没有显着差异。与基线相比，3 个月时发现 CWS、UPDRS ADL 和总分存在显着差异。 结论：除了 NIT 之外，PD 患者在短期内还可以从 PT 组治疗中获益，包括与活动能力、CWS 和 ADL 相关的生活质量；在 CWS、UPDRS ADL 和总分方面发现了长期益处，但各组之间存在差异。
Objective: To investigate the effects of a physical therapy (PT) program in groups of people with Parkinson's disease (PD).Design: Randomized controlled trial with a crossover design. Setting: Two outpatient rehabilitation clinics in Boston and Amsterdam, respectively.Participants: Sixty-eight Subjects diagnosed with typical, idiopathic PD, Hoehn and Yahr stage II or III, and stable medication use.Intervention: Group A received PT and medication therapy (MT) for the first 6 weeks, followed by MT only for the second 6 weeks. Group B received only MT for the first 6 weeks and PT and MT for the second 6 weeks.Main Outcome Measures: The Sickness Impact Profile (SIP-68), the mobility portion of the SIP-68, the Unified Parkinson's Disease Rating Scale (UPDRS), and comfortable walking speed (CWS) at baseline, 6-week, 12-week, and 3-month follow-up.Results: At 6 weeks, differences between groups were significant for the SIP mobility (P = .015; effect size [ES] = .55), for CWS (P = .012; ES = .49), for the activities of daily living (ADL) section of the UPDRS (P = .014; ES = .45), and for the total UPDRS (P = .007; ES = .56). The total SIP and the mentation and motor sections of the UPDRS did not differ significantly between groups. Significant differences were found at 3 months compared with baseline for CWS, the UPDRS ADL, and total scores.Conclusions: People with PD derive benefits in the short term from PT group treatment, in addition to their NIT, for quality of life related to mobility, CWS, and ADLs; long-term benefits were found in CWS, UPDRS ADL, and total scores but varied between groups.