Pore timing: the evolutionary origins of the nucleus and nuclear pore complex.
Pore timing: the evolutionary origins of the nucleus and nuclear pore complex.
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DOI：
10.12688/f1000research.16402.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Rout, Michael P
中科院分区：
文献类型：
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作者：
Field, Mark C;Rout, Michael P
“真核生物”一词源自希腊语，意思是“真正的内核”，描述了细胞具有细胞核的生物体的领域。因此，细胞核是真核生物的决定性特征，并将其与原核生物（古细菌和细菌）区分开来，原核生物的细胞缺乏细胞核。尽管如此，我们还是讨论了一个有趣的可能性，即从第一个真核生物共同祖先到所有真核生物最后一个共同祖先的过程中，生物体根本不拥有细胞核——至少不是我们今天所认识的形式——而且细胞核实际上在真核生物进化过程中相对较晚出现。这种替代进化路径的线索最重要的是最近关于核孔复合体结构的发现。我们讨论了这种可能性的证据，以及这如何影响我们对真核生物起源的看法，以及真核生物在它们最后一个共同祖先之后如何多样化。
The name "eukaryote" is derived from Greek, meaning "true kernel", and describes the domain of organisms whose cells have a nucleus. The nucleus is thus the defining feature of eukaryotes and distinguishes them from prokaryotes (Archaea and Bacteria), whose cells lack nuclei. Despite this, we discuss the intriguing possibility that organisms on the path from the first eukaryotic common ancestor to the last common ancestor of all eukaryotes did not possess a nucleus at all-at least not in a form we would recognize today-and that the nucleus in fact arrived relatively late in the evolution of eukaryotes. The clues to this alternative evolutionary path lie, most of all, in recent discoveries concerning the structure of the nuclear pore complex. We discuss the evidence for such a possibility and how this impacts our views of eukaryote origins and how eukaryotes have diversified subsequent to their last common ancestor.