Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos
Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos
复制标题
DOI：
10.1136/heartjnl-2018-313463
复制
发表时间：
2019-03-01
期刊：
影响因子：
5.7
通讯作者：
Argos, Maria
中科院分区：
文献类型：
--
作者：
Bulka, Catherine M.;Daviglus, Martha L.;Argos, Maria
目的 心血管疾病 (CVD) 是美国死亡率和发病率的主要原因。尽管许多化学物质具有心脏毒性，但很少有人研究职业接触化学物质在 CVD 发展中的作用。 We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers.Methods Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed.来自美国四个城市的参与者提供了问卷数据并接受了包括心电图在内的临床检查。 CVD被定义为至少存在以下一种情况：冠心病、心房颤动、心力衰竭或脑血管疾病。使用泊松回归模型计算反映每种职业暴露与 CVD 以及 CVD 亚型之间关系的患病率。 结果 西班牙裔/拉丁裔工人报告在其当前工作中接触过有机溶剂 (6.5%)、金属 (8.5%) 和农药 (4.7%)。总体而言，6.1% 的参与者患有某种形式的心血管疾病，其中最常见的是冠心病 (4.3%)，其次是脑血管疾病 (1.0%)、心力衰竭 (0.8%) 和心房颤动 (0.7%)。对于自称从事农药工作的个人，任何心血管疾病的患病率分别为 2.18（95% CI 1.34 至 3.55）、冠心病 2.20（95% CI 1.31 至 3.71）、脑血管疾病 1.38（95% CI 0.62 3.03）、心力衰竭 0.91（95% CI 0.23 至 3.71）。 3.54) 和心房颤动 5.92 （95% CI 1.89 至 18.61）调整社会人口、文化适应、生活方式和职业特征后。金属暴露与房颤患病率增加近四倍（3.78，95% CI 1.24 至 11.46）相关。有机溶剂暴露观察到零关联。结论我们的结果表明，使用金属和农药可能是西班牙裔/拉丁裔工人发生 CVD 的危险因素。需要进一步的工作来前瞻性地评估这些关系。
Objective Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers.Methods Cross-sectional data from 7404 employed individuals, aged 18-74 years, enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) were analysed. Participants from four US cities provided questionnaire data and underwent clinical examinations, including ECGs. CVD was defined as the presence of at least one of the following: coronary heart disease, atrial fibrillation, heart failure or cerebrovascular disease. Prevalence ratios reflecting the relationship between each occupational exposure and CVD as well as CVD subtypes were calculated using Poisson regression models.Results Hispanic/Latino workers reported exposures to organic solvents (6.5%), metals (8.5%) and pesticides (4.7%) at their current jobs. Overall, 6.1% of participants had some form of CVD, with coronary heart disease as the most common (4.3%) followed by cerebrovascular disease (1.0%), heart failure (0.8%) and atrial fibrillation (0.7%). For individuals who reported working with pesticides, the prevalence ratios for any CVD were 2.18 (95% CI 1.34 to 3.55), coronary heart disease 2.20 (95% CI 1.31 to 3.71), cerebrovascular disease 1.38 (95% CI 0.62 3.03), heart failure 0.91 (95% CI 0.23 to 3.54) and atrial fibrillation 5.92 (95% CI 1.89 to 18.61) after adjustment for sociodemographic, acculturation, lifestyle and occupational characteristics. Metal exposures were associated with an almost fourfold (3.78, 95% CI 1.24 to 11.46) greater prevalence of atrial fibrillation. Null associations were observed for organic solvent exposures.Conclusions Our results suggest that working with metals and pesticides could be risk factors for CVD among Hispanic/Latino workers. Further work is needed to evaluate these relationships prospectively.