Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China
Identification and susceptibility of Rhizomucor spp. isolated from patients with cutaneous zygomycosis in China
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DOI：
10.3109/13693786.2011.571292
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发表时间：
2011-11-01
期刊：
影响因子：
2.9
通讯作者：
Yu, Jin
中科院分区：
文献类型：
--
作者：
Wang, Si-Bu;Li, Ruo-Yu;Yu, Jin
接合菌病是一种相对少见的真菌病，其发病率在世界范围内呈上升趋势。皮肤真菌病是该病的临床表现之一，近几十年来也出现了。在中国报道的主要病原体包括根毛霉属，根霉属，毛霉属，和Lichtheimia spp.（原Absidia spp.）。本研究检测了11株根毛霉临床分离株，分别属于3个种（R. variabilis，R. regularior，和R.厚垣孢子菌属）。通过形态学和分子生物学方法对它们进行了鉴定，发现它们具有高度的相关性。测试了根毛霉分离株对七种抗真菌药物（两性霉素B、伊曲康唑、特比萘芬、伏立康唑、氟康唑、氟胞苷和米卡芬净）的体外敏感性，结果发现两性霉素B是对本研究中评估的所有物种最有效的药物。该调查还审查了中国皮肤真菌病的病例报告。
Zygomycosis is a relatively uncommon mycosis with a morbidity that is increasing worldwide. Cutaneous zygomycosis, one of the clinical manifestations of the disease, has also emerged in recent decades. The major reported etiologic agents in China include Rhizomucor spp., Rhizopus spp., Mucor spp., and Lichtheimia spp. (formerly Absidia spp.). This study examined 11 clinical isolates of Rhizomucor that belong to three species (R. variabilis, R. regularior, and R. chlamydosporus). They were identified by both morphological and molecular methods and were found to have a high degree of correlation. In vitro susceptibility of the Rhizomucor isolates to seven antifungal drugs (amphotericin B, itraconazole, terbinafine, voriconazole, fluconazole, flucytosine, and micafungin) were tested, which resulted in amphotericin B being found to be the most active agent against all species evaluated in this study. The investigation also reviewed case reports of cutaneous zygomycosis in China.