Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
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DOI：
10.1073/pnas.95.15.8892
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发表时间：
1998-07-21
影响因子：
11.1
通讯作者：
Beal, MF
中科院分区：
文献类型：
--
作者：
Matthews, RT;Yang, LC;Beal, MF
辅酶Q（10）是电子传递链的一个重要辅因子，也是脂质和线粒体膜中一种有效的自由基清除剂。在12个月和24个月大的大鼠中，喂食辅酶Q（10）增加了大脑皮层的浓度。在12个月大的大鼠中给予辅酶Q（10）导致大脑皮层线粒体辅酶Q（10）浓度的显著增加。口服辅酶Q（10）显著减轻了由全身给予3-硝基丙酸引起的纹状体损伤，并显著延长了家族性肌萎缩侧索硬化症转基因小鼠模型的寿命。这些结果表明，口服辅酶Q（10）可增加脑和脑线粒体浓度。他们提供了进一步的证据，证明辅酶Q（10）可以发挥神经保护作用，可能有助于治疗神经退行性疾病。
Coenzyme Q(10) is an essential cofactor of the electron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q(10) increased cerebral cortex concentrations in 12- and 24-month-old rats. In 12-month-old rats administration of coenzyme Q(10) resulted in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q(10) Oral administration of coenzyme Q(10) markedly attenuated striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increased life span in a transgenic mouse model of familial amyotrophic lateral sclerosis. These results show that oral administration of coenzgme Q(10) increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q(10) can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.