The lack of an effect of intraocular steroids on irradiated fibroblasts in experimental proliferative vitreoretinopathy.
The lack of an effect of intraocular steroids on irradiated fibroblasts in experimental proliferative vitreoretinopathy.
复制标题
眼内类固醇对实验性增殖性玻璃体视网膜病变中受辐射的成纤维细胞缺乏作用。
DOI：
10.1007/bf00164662
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Machemer,R
中科院分区：
文献类型：
--
作者：
Chandler,DB;Hida,T;Rozakis,G;Forbes,VS;Machemer,R
Contraction of intraocular membranes is an important event in the development of proliferative vitreoretinopathy (PVR). When sufficient numbers of cells are present in the vitreous cavity, the retina usually detaches as a result of the contractive force generated by these cells. Steroids reduce the occurrence of retinal detachments in rabbit models of PVR by inhibiting the proliferation of injected fibroblasts. In this study, we used non-proliferative, irradiated cells to determine a possible effect of steroids on preretinal membrane contraction in PVR. We found no clinical difference between steroid treated eyes and sham-treated control eyes. Surgical reduction of the contractile tissue and medical therapy to prevent reproliferation are necessary in order to treat PVR effectively.
