Roles of alcohol consumption in fatty liver: A longitudinal study
Roles of alcohol consumption in fatty liver: A longitudinal study
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DOI：
10.1016/j.jhep.2014.11.025
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发表时间：
2015-04-01
影响因子：
25.7
通讯作者：
Yamamoto, Kazuhide
中科院分区：
文献类型：
--
作者：
Moriya, Akio;Iwasaki, Yoshiaki;Yamamoto, Kazuhide
背景和目标：酒精消费在非酒精性脂肪肝疾病中的作用仍然存在争议，尽管一些横断面研究表明轻度至中度饮酒对脂肪肝的有益影响。我们分析了饮酒模式和脂肪liver.Methods之间的纵向关系：我们包括5297日本人（3773名男性和1524名女性）谁在2003年进行了基线研究，并随访至少一次，从2004年至2006年。广义估计方程被用来估计任何饮酒模式和脂肪肝之间的关联评估ultrasounds.Results：在基线，1179名男性（31.2%）和235名女性（15.4%）有脂肪肝; 2802名男性（74.2%）和436名女性（28.6%）报告饮酒。在最近的随访中，2594名男性中有348名（13.4%）和1289名女性中有101名（7.8%）新发脂肪肝; 1179名男性中有285名（24.2%）和235名女性中有70名（29.8%）表现出脂肪肝缓解。男性，每周饮用0.1-69.9 g（比值比，0.79 [95%置信区间，0.68-0.90]），饮酒70.0-139.9 g/周（0.73 [0.63-0.84]）、饮酒140.0-279.9 g/周（0.69 [0.60-0.79]）和饮酒≥ 280.0 g/周（0.68 [0.58-0.79]）与脂肪肝呈负相关，在调整肥胖、运动和吸烟后。女性每周饮用0.1-69.9 g（0.71 [0.52-0.96]）和饮水70.0-139.9 g/周（0.67 [0.45-0.98]）与校正后的脂肪肝呈负相关。轻度至中度饮酒，甚至过量，尤其是男性，随着时间的推移，可能会保护大多数人免受脂肪肝。(C)2014年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background & Aims: Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver.Methods: We included 5297 Japanese individuals (3773 men and 1524 women) who underwent a baseline study in 2003 and follow-up at least once from 2004 to 2006. Generalized estimating equation was used to estimate any association between drinking pattern and fatty liver assessed by ultrasonography.Results: At baseline, 1179 men (31.2%) and 235 women (15.4%) had fatty liver; 2802 men (74.2%) and 436 women (28.6%) reported alcohol consumption. At the latest follow-up, 348 of 2594 men (13.4%) and 101 of 1289 women (7.8%) had newly developed fatty liver; 285 of 1179 men (24.2%) and 70 of 235 women (29.8%) demonstrated a remission of fatty liver. In men, drinking 0.1-69.9 g/week (odds ratio, 0.79 [95% confidence interval, 0.68-0.90]), drinking 70.0-139.9 g/week (0.73 [0.63-0.84]), drinking 140.0-279.9 g/week (0.69 [0.60-0.79]), and drinking >= 280.0 g/week (0.68 [0.58-0.79]) were inversely associated with fatty liver after adjusting for obesity, exercise, and smoking. In women, drinking 0.1-69.9 g/week (0.71 [0.52-0.96]) and drinking 70.0-139.9 g/week (0.67 [0.45-0.98]) were inversely associated with fatty liver after the adjustment.Conclusions: Light to moderate alcohol consumption, or even somewhat excessive amounts especially in men, was likely to protect most individuals against fatty liver over time. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.