Trigeminal perception of odorant quality in congenitally anosmic subjects
Trigeminal perception of odorant quality in congenitally anosmic subjects
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DOI：
10.1093/chemse/22.4.447
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发表时间：
1997-08-01
期刊：
影响因子：
3.5
通讯作者：
Hudson, R
中科院分区：
文献类型：
--
作者：
Laska, M;Distel, H;Hudson, R
对20名先天无嗅觉受试者和50名正常受试者进行了测试，测试他们的能力：(I)从三叉神经型描述符列表中将语言标签分配给据信具有较强三叉神经成分的六种气味；(Ii)在奇数球范式中区分强度匹配的这些气味对。结果发现：正常对照组判断薄荷脑和桉树脑明显凉爽和新鲜，醋酸为辛辣和酸，丙酮为辛辣，但没有显示乙醇和丙醇的清晰描述特征。无嗅觉受试者对六种气味(薄荷醇、桉树酚和乙醇)中的三种给出的描述性特征与对照组给出的描述性特征显著相关，证实了所描述的感觉确实可能是由三叉神经系统介导的。在奇数球测试中，对照组受试者在呈现的九个项目中平均正确识别了八个项目，其中大多数错误发生在具有相似三叉神经轮廓的配对的反应中。在9个项目中，平均有7.2项是正确的，无渗受试者的表现与正常受试者没有显著差异，但在区分醋酸和薄荷醇方面。虽然有必要进行额外的测试来最终确定刺激强度的差异是否可能是导致这种良好的辨别性能的原因，但目前的结果表明，鼻三叉神经系统可能对气味质量的感知有显著影响。
Twenty congenitally anosmic subjects and 50 normosmic controls were tested for their ability (i) to assign verbal labels from a list of trigeminal-type descriptors to six odorants believed to have a strong trigeminal component; and (ii) to discriminate between intensity-matched pairs of these odorants in an odd-ball paradigm. The following was found: normosmic controls judged menthol and cineole as distinctly cool and fresh, acetic acid as pungent and sour, and acetone as pungent, but showed no clear descriptive profile for ethanol and propanol. The descriptive profiles given by the anosmic subjects correlated significantly with those given by the controls for three of the six odorants (menthol, cineol and ethanol), confirming that the sensations described may indeed be mediated by the trigeminal system. In the odd-ball test, the control subjects correctly identified an average of eight out of the nine items presented, with most mistakes occurring in response to pairs with a similar trigeminal profile. With an average of 7.2 of nine items correct, the performance of the anosmic subjects was not significantly different to that of the normosmics, except in discriminating between acetic acid and menthol. Although additional tests are necessary to decide finally whether differences in stimulus intensity may have contributed to this good discriminatory performance, the present results suggest that the nasal trigeminal system may contribute significantly to the perception of odor quality.