Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy
Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy
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DOI：
10.1046/j.1460-9568.2002.02138.x
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发表时间：
2002-08-01
影响因子：
3.4
通讯作者：
Davis, M
中科院分区：
文献类型：
--
作者：
Davis, M
向杏仁核（兴奋性恐惧调节所必需的大脑区域）注入 NMDA 受体拮抗剂或 NMDA 受体相关丝裂原激活蛋白激酶级联的抑制剂会阻止消退学习。相反，NMDA 受体激动剂 d-环丝氨酸在全身给药或杏仁核内输注后促进消退。由于基于消退过程的治疗干预通常用于治疗恐惧症，并且由于 d-环丝氨酸是一种广泛使用且安全的化合物，因此 d-环丝氨酸或类似药物可能与传统的基于消退的方法有效结合，治疗临床恐惧。
Infusions into the amygdala (a brain area essential for excitatory fear conditioning) of either NMDA receptor antagonists or inhibitors of the NMDA receptor-linked mitogen activated protein kinase cascade block extinction learning. Conversely, the NMDA receptor agonist d-cycloserine facilitates extinction after either systemic administration or intra-amygdala infusion. Because therapeutic interventions based on extinction procedures are commonly used to treat fear disorders, and because d-cycloserine is a widely available and safe compound, d-cycloserine or similar agents might be usefully combined with traditional extinction-based approaches in the treatment of clinical fear.