Riluzole-induced lung injury in two patients with amyotrophic lateral sclerosis.
Riluzole-induced lung injury in two patients with amyotrophic lateral sclerosis.
复制标题
两名肌萎缩侧索硬化症患者利鲁唑引起的肺损伤。
DOI：
10.2169/internalmedicine.51.6522
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发表时间：
2012
影响因子：
1.2
通讯作者：
Y. Fukushima
中科院分区：
文献类型：
--
作者：
T. Kakuta;H. Hirata;Sayo Soda;T. Shiobara;M. Watanabe;M. Tatewaki;F. Fukushima;K. Chibana;K. Sugiyama;M. Arima;H. Koichi;T. Fukuda;Y. Fukushima
利鲁唑最近被证明是治疗肌萎缩性侧索硬化症（ALS）的第一种有效药物。我们报告两例罕见的肺损伤患者利鲁唑治疗引起的ALS。胸片显示双侧下肺叶，背侧显性磨玻璃影和/或实变。外周血或支气管肺泡灌洗细胞药物淋巴细胞刺激试验（DLST）对利鲁唑阳性。肺活检标本的组织病理学检查显示肺损伤，无真菌样肉芽肿、血管炎或弥漫性肺泡损伤。据我们所知，这是首例利鲁唑致肺损伤并伴有DLST阳性结果的报道。
Riluzole has recently been proven as the first effective drug for the treatment of amyotrophic lateral sclerosis (ALS). We report two rare cases of lung injury caused by riluzole therapy in patients with ALS. Chest radiographs showed bilateral lower lobe, dorsal-dominant ground glass opacity, and/or consolidation. A drug lymphocyte stimulation test (DLST) of peripheral blood or bronchoalveolar lavage cells was positive for riluzole. Histopathological examination of lung biopsy specimens revealed lung injury without fungoid granuloma, vasculitis, or diffuse alveolar damage. To the best of our knowledge, this is the first report of riluzole-induced lung injury with positive DLST results.