Association of 25-hydroxyvitamin D with the incidence of knee and hip osteoarthritis: a 22-year follow-up study
Association of 25-hydroxyvitamin D with the incidence of knee and hip osteoarthritis: a 22-year follow-up study
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DOI：
10.3109/03009742.2011.617314
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发表时间：
2012-01-01
影响因子：
2.1
通讯作者：
Karppinen, J.
中科院分区：
文献类型：
--
作者：
Konstari, S.;Paananen, M.;Karppinen, J.
目的：鉴于先前关于维生素D作用的研究结果相互矛盾，我们研究了血清25-羟基维生素D [25（OH）D]对膝关节和髋关节骨关节炎（OA）的预测作用。研究人群（n = 805）由国家健康检查调查的参与者组成，他们每隔20-23年进行一次基线和随访临床检查。膝关节和髋关节骨性关节炎的诊断基于医生在基线和随访时采用相同诊断标准的标准化临床检查。在基线时收集协变量的信息，包括年龄、性别、抽血季节、教育、体重指数（BMI）、体力工作量、休闲时间体力活动、吸烟史和既往受伤史。血清25（OH）D浓度从基线血清样本保持冷冻在-20 ℃。结果：我们发现血清25（OH）D水平和事件膝关节或髋关节OA的风险之间没有显着的关联。然而，在预测明确膝关节OA的发生时，采血季节和血清25（OH）D之间出现了统计学显著的相互作用（p 0.004）。调整所有协变量后，（95%置信区间）每增加1 SD，发生明确膝关节OA（20.7 ng/mL），冬季25（OH）D为1.57（1.10-2.27），而夏季血清的相应比率为0.53（0.28-1.00）。结论：本研究结果不支持低水平血清25（OH）D与OA发生有关的假设。相反，我们的研究表明，季节是25（OH）D的有效调节剂，值得在未来的研究中关注。
Objective: In the light of conflicting results from previous studies on the role of vitamin D, we studied serum 25-hydroxyvitamin D [25(OH) D] with regard to its prediction of incident knee and hip osteoarthritis (OA).Methods: The study population (n = 805) consisted of participants of a national health examination survey who had undergone baseline and follow-up clinical examinations at intervals of 20-23 years. Knee and hip OA were diagnosed on the basis of a standardized clinical examination by physicians with the same diagnostic criteria at baseline and follow-up. Information on covariates, including age, sex, season of blood draw, education, body mass index (BMI), physical workload, leisure time physical activity, smoking history, and previous injuries, was collected at baseline. Serum 25(OH) D concentrations were determined from baseline serum samples kept frozen at -20 degrees C.Results: We found no significant association between serum 25(OH) D level and the risk of incident knee or hip OA. However, a statistically significant interaction between season of blood draw and serum 25(OH) D emerged when predicting the development of definite knee OA (p 0.004). After adjusting for all the covariates, the relative odds (95% confidence interval) of developing definite knee OA per increment of 1 SD (20.7 ng/mL) in winter season 25(OH) D was 1.57 (1.10-2.27), whereas for summer season sera the corresponding rate was 0.53 (0.28-1.00).Conclusion: The results do not support the hypothesis that a low level of serum 25(OH) D contributes to the development of OA. Instead, our study suggests that season is a potent effect modifier of 25(OH) D, which merits attention in future research.