Metabolic switching and fuel choice during T-cell differentiation and memory development.
Metabolic switching and fuel choice during T-cell differentiation and memory development.
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DOI：
10.1111/j.1600-065x.2012.01150.x
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发表时间：
2012-09
影响因子：
8.7
通讯作者：
Pearce EL
中科院分区：
文献类型：
--
作者：
van der Windt GJ;Pearce EL
清除或控制病原体或肿瘤通常需要t细胞介导的免疫。因此，了解控制T细胞功能、维持和持久性的机制可能会导致控制疾病的新疗法。在免疫应答过程中，t细胞的发育以代谢的显著变化为标志。越来越多的人认识到，这些代谢变化是T细胞执行特定功能的能力的基础，这导致了最近对细胞代谢的操纵可以用来形成适应性免疫反应的想法的关注。尽管对这一领域的兴趣在过去几年中有所增长，但对t细胞功能的代谢控制的充分理解，特别是在体内免疫反应期间，仍然缺乏。在这篇综述中，我们首先提供了T细胞代谢的基本概述，然后我们关注最近的研究提供了新的或更新的见解，代谢途径的调节以及它们如何支持T细胞分化和记忆T细胞的发育。
Clearance or control of pathogens or tumors usually requires T-cell-mediated immunity. As such, understanding the mechanisms that govern the function, maintenance, and persistence of T cells will likely lead to new treatments for controlling disease. During an immune response, T-cell development is marked by striking changes in metabolism. There is a growing appreciation that these metabolic changes underlie the capacity of T cells to perform particular functions, and this has led to a recent focus on the idea that the manipulation of cellular metabolism can be used to shape adaptive immune responses. Although interest in this area has grown in the last few years, a full understanding of the metabolic control of T-cell functions, particularly during an immune response in vivo, is still lacking. In this review, we first provide a basic overview of metabolism in T cells, and then we focus on recent studies providing new or updated insights into the regulation of metabolic pathways and how they underpin T-cell differentiation and memory T-cell development.