Vagal Neural Crest Cell Migratory Behavior: A Transition Between the Cranial and Trunk Crest
Vagal Neural Crest Cell Migratory Behavior: A Transition Between the Cranial and Trunk Crest
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DOI：
10.1002/dvdy.22715
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发表时间：
2011-09-01
影响因子：
2.5
通讯作者：
Erickson, Carol A.
中科院分区：
文献类型：
--
作者：
Kuo, Bryan R.;Erickson, Carol A.
颅神经嵴细胞的迁移和分化在很大程度上是由环境因素控制的，而在躯干水平的寻路是由细胞自主的分子变化，由于早期规范的premigratory嵴。在这里，我们调查了迷走神经嵴细胞的迁移和图案。我们表明：（1）迷走神经嵴细胞表现出一些发育偏好，（2）它们采取不同的途径到达心脏和肠道。总之，这些观察结果表明，先前的规格决定了初始途径的选择。然而，当我们用不同的迁移环境挑战迷走神经嵴细胞时，我们观察到前迷走神经嵴细胞（体节水平1-3）的行为表现出相当大的迁移可塑性，而后迷走神经嵴细胞（体节水平5-7）的行为受到更多的限制。我们的结论是迷走神经嵴是一个过渡人口之间的头部和躯干的发展。发展动力学240：2084-2100，2011年。(C)2011 Wiley-Liss，Inc.
Migration and differentiation of cranial neural crest cells are largely controlled by environmental cues, whereas pathfinding at the trunk level is dictated by cell-autonomous molecular changes owing to early specification of the premigratory crest. Here, we investigated the migration and patterning of vagal neural crest cells. We show that (1) vagal neural crest cells exhibit some developmental bias, and (2) they take separate pathways to the heart and to the gut. Together these observations suggest that prior specification dictates initial pathway choice. However, when we challenged the vagal neural crest cells with different migratory environments, we observed that the behavior of the anterior vagal neural crest cells (somite-level 1-3) exhibit considerable migratory plasticity, whereas the posterior vagal neural crest cells (somite-level 5-7) are more restricted in their behavior. We conclude that the vagal neural crest is a transitional population that has evolved between the head and the trunk. Developmental Dynamics 240:2084-2100, 2011. (C) 2011 Wiley-Liss, Inc.