Central osmotic regulation of sympathetic nerve activity.

Central osmotic regulation of sympathetic nerve activity.
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交感神经活动的中枢渗透调节。

DOI:
10.1046/j.1365-201x.2003.01046.x
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发表时间:
2003
期刊:
Acta physiologica Scandinavica.
影响因子:
--
通讯作者:
Stocker,SD
Stocker,SD
中科院分区:
--
文献类型:
--
作者:
Toney,GM;Chen,QH;Cato,MJ;Stocker,SD

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Aim:In this review, we will focus on the central neural mechanisms that couple osmotic perturbations to changes in sympathetic nerve discharge, and the possible impact these actions have in cardiovascular diseases such as arterial hypertension and congestive heart failure.Results:Changes in extracellular fluid osmolality lead to specific regulatory responses in defence of body fluid and cardiovascular homeostasis. Systemic hyperosmolality is well known to stimulate thirst and the release of antidiuretic hormone. These responses are largely due to osmosensing neurones in the forebrain lamina terminalis and hypothalamus and are critical elements in a control system that operates to restore body fluid osmolality. An equally important, but less characterized, target of central osmoregulatory processes is the sympathetic nervous system.Conclusion:Understanding the neurobiology of sympathetic responses to changes in osmolality has important implications for body fluid and cardiovascular physiology. By stabilizing osmolality, vascular volume is preserved and thereby relatively normal levels of cardiac output and arterial pressure are maintained.
DOI: 10.1152/ajpregu.2001.280.3.r831
发表时间: 2001-03
期刊: American journal of physiology. Regulatory, integrative and comparative physiology
影响因子: --
作者:
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DOI: --
发表时间: 1998
影响因子: --
作者:
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通讯作者: C. Bourque
DOI: --
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期刊: Brain Research
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