The micromechanical environment of intervertebral disc cells: Effect of matrix anisotropy and cell geometry predicted by a linear model
The micromechanical environment of intervertebral disc cells: Effect of matrix anisotropy and cell geometry predicted by a linear model
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DOI：
10.1115/1.429655
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发表时间：
2000-06-01
影响因子：
1.7
通讯作者：
Setton, LA
中科院分区：
文献类型：
--
作者：
Baer, AE;Setton, LA
椎间盘细胞在表型和形态上表现出空间差异，这可能与它们局部机械环境的差异有关。在这项研究中，我们使用nit分析模型研究了椎间盘细胞内部和周围的应力、应变和扩张，该模型将椎间盘细胞视为嵌入横向各向同性基质中的机械包涵体。由于基质的拉伸，细胞的局部力学环境在椎间盘的解剖区域之间是不同的，并且受到基质各向异性和细胞几何参数变化的强烈影响。本研究结果表明，局部细胞力学环境可能在决定细胞原位形态和观察到的椎间盘细胞对机械载荷的不均匀响应中起作用。
Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences bl their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with nit analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile lending of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc.