Is mid-life social participation associated with cognitive function at age 50? Results from the British National Child Development Study (NCDS).
Is mid-life social participation associated with cognitive function at age 50? Results from the British National Child Development Study (NCDS).
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DOI：
10.1186/s40359-016-0164-x
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发表时间：
2016-12-02
期刊：
影响因子：
3.6
通讯作者：
Dodgeon B
中科院分区：
文献类型：
--
作者：
Bowling A;Pikhartova J;Dodgeon B
一些研究表明，社会参与与更好的认知结果有关。本研究旨在调查50岁时生活过程社会参与（公民参与）和认知状态之间的关联，调整社交网络和支持，行为，健康，社会和社会经济特征。该研究的载体是国家儿童发育研究（1958年出生队列研究），这是英格兰，苏格兰和威尔士的一般人群样本（9119：4497名男性和4622名女性），参与全国代表性的前瞻性出生队列调查。主要结果变量是50岁时的认知状态，通过记忆测试（即时和延迟单词回忆测试）和执行功能测试（单词流畅性和字母取消测试）进行测量。采用线性多元回归分析假设的预测变量的影响。11岁时的认知能力（β = 0.19;95% CI = 0.17 - 0.21），33岁时参与公民活动（0.12; 0.02至0.22）和50（0.13; 0.07至0.20），经常参加体育活动（运动）（β从0.15到0.18），获得更高级别的资格（β = 0.23 ~ 1.08）和女性（β = 0.49; 95%CI = 0.38 ~ 0.60）与50岁时的认知状态呈正相关、显著相关和独立相关。在11岁（β从-0.22到-0.27）和42岁（β从-0.28到-0.38）时社会经济地位低，在42岁时表现出更差的心理健康（β = -0.18; 95% CI = -0.33到-0.02）与50岁时的认知状态呈负相关。在多元回归模型中解释方差的比例（18%），虽然适度，但考虑到认知状态的多方面因果性质，令人印象深刻。结果表明，在调整了包括健康，社会经济地位和性别在内的协变量后，成年人的社会参与和50岁时的认知功能之间的适度关联仍然存在，支持神经可塑性理论。除了继续强调体育活动外，鼓励公民参与，至少早在中年，应该是一项有针对性的政策，以促进和保护中年后期的认知功能。本文的在线版本（doi：10.1186/s40359-016-0164-x）包含补充材料，可供授权用户使用。
Some studies have indicated that social engagement is associated with better cognitive outcomes. This study aimed to investigate associations between life-course social engagement (civic participation) and cognitive status at age 50, adjusting for social networks and support, behavioural, health, social and socio-economic characteristics. The vehicle for the study was the National Child Development Study (1958 Birth Cohort Study), which is a general population sample in England, Scotland and Wales (9119: 4497 men and 4622 women) participating in nationally representative, prospective birth cohort surveys. The primary outcome variable was cognitive status at age 50, measured by memory test (immediate and delayed word recall test) and executive functioning test (word fluency and letter cancelation tests). The influence of hypothesised predictor variables was analysed using linear multiple regression analysis. Cognitive ability at age 11 (β = 0.19;95% CI = 0.17 to 0.21), participation in civic activities at ages 33 (0.12; 0.02 to 0.22) and 50 (0.13; 0.07 to 0.20), frequent engagement in physical activity (sport) (β from 0.15 to 0.18), achieving higher level qualifications (β from 0.23 to 1.08), and female gender (β = 0.49;95% CI = 0.38 to 0.60) were positively, significantly and independently associated with cognitive status at age 50. Having low socio-economic status at ages 11 (β from -0.22 to -0.27) and 42 (β from -0.28 to -0.38), and manifesting worse mental well-being at age 42 (β = -0.18; 95% CI = -0.33 to -0.02) were inversely associated with cognitive status at age 50. The proportion of explained variance in the multiple regression model (18%), while modest, is impressive given the multi-faceted causal nature of cognitive status. The results indicate that modest associations between adult social engagement and cognitive function at age 50 persist after adjusting for covariates which included health, socio-economic status and gender, supporting theories of neuroplasticity. In addition to the continuing emphasis on physical activity, the encouragement of civic participation, at least as early as mid-life, should be a targeted policy to potentially promote and protect cognitive function in later mid-life. The online version of this article (doi:10.1186/s40359-016-0164-x) contains supplementary material, which is available to authorized users.