Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer.
Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer.
复制标题
骨髓源性抑制细胞的表观遗传学：通往癌症的一把出鞘的剑
DOI：
10.18632/oncotarget.10767
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发表时间：
2016-08-30
期刊：
影响因子：
--
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Zhang C;Wang S;Liu Y;Yang C
Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells composed of progenitors and precursors to myeloid cells, are deemed to participate in the development of tumor-favoring immunosuppressive microenvironment. Thus, the regulatory strategies targeting MDSCs' expansion, differentiation, accumulation and function could possibly be effective “weapons” in anti-tumor immunotherapies. Epigenetic mechanisms, which involve DNA modification, covalent histone modification and RNA interference, result in the heritable down-regulation or silencing of gene expression without a change in DNA sequences. Epigenetic modification of MDSC's functional plasticity leads to the remodeling of its characteristics, therefore reframing the microenvironment towards countering tumor growth and metastasis. This review summarized the pertinent findings on the DNA methylation, covalent histone modification, microRNAs and small interfering RNAs targeting MDSC in cancer genesis, progression and metastasis. The potentials as well as possible obstacles in translating into anti-cancer therapeutics were also discussed.
