High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients
High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients
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DOI：
10.1016/j.metabol.2017.03.014
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发表时间：
2017-06-01
影响因子：
9.8
通讯作者：
Giralt, Marta
中科院分区：
文献类型：
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作者：
Gallego-Escuredo, Jose M.;Karuna Lamarca, Maria;Giralt, Marta
背景资料。成纤维细胞生长因子-21(FGF21)是糖、脂和体重动态平衡的重要调节因子。然而，最近的实验研究报道，FGF21水平升高可能导致骨丢失。目的：探讨HIV-1感染者血清FGF21水平与骨稳态改变的关系。在巴塞罗那圣保罗医院对137名HIV-1感染者和35名健康对照进行了横断面研究。在HIV-1感染患者中，35例未经治疗(朴素)，43例接受抗逆转录病毒治疗(HIV-1/ART)，没有脂肪营养不良，59例HIV-1/ART患者经历了脂肪营养不良。采用双能X线骨密度仪测定骨密度(BMD)和骨密度(BMC)。采用酶联免疫吸附试验检测血清FGF21、核因子受体激活剂-KB配体(RANKL)和I型胶原C-端肽(CTX-1)水平。血清骨钙素、骨保护素、瘦素、肿瘤坏死因子-α、白介素6、白介素8和单核细胞趋化蛋白-1的水平通过抗体连接的微球荧光标记微球多重分析系统进行检测。在HIV-1感染患者中，骨参数和骨稳态标记物水平的变化与较高的周转率和骨丢失一致。FGF21与BMD、BMC呈负相关。FGF21与血清护骨素、CTX-1水平及CTX-1/骨钙素比值呈正相关。在HIV-1感染的患者中，FGF21水平升高与骨骼平衡不良有关。血清FGF21水平的升高可能不仅是代谢紊乱的指标，也可能是HIV-1感染患者骨稳态改变的生物标志物。(C)2017 Elsevier Inc.保留所有权利。
Background. Fibroblast growth factor-21 (FGF21) has emerged as an important regulator of glucose, lipid, and body weight homeostasis. However, recent experimental studies have reported that increased FGF21 levels may lead to bone loss.Objective. To assess the relationship of serum FGF21 levels and altered bone homeostasis in HIV-1-infected patients.Design. Cross-sectional study of 137 HIV-1-infected patients and 35 healthy controls conducted at the Hospital de la Santa Creu i Sant Pau, Barcelona. Among HIV-1-infected patients, 35 were untreated (naive), 43 were treated with antiretrovirals (HIV-1/ART) with no lipodystrophy, and 59 patients were HIV-1/ART and experienced lipodystrophy. Bone mineral density (BMD) and content (BMC) were assessed using dual-energy X-ray absorptiometry. Serum levels of FGF21, receptor activator of nuclear factor (NF)-KB ligand (RANKL), and C-telopeptide of type-I collagen (CTX-1) were measured by enzyme-linked immunosorbent assays. Serum levels of osteocalcin, osteoprotegerin, leptin, tumor necrosis factor-alpha, interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 were determined using an antibody-linked, fluorescently labeled microsphere bead-based multiplex analysis system.Results. Alterations in bone parameters and bone homeostasis marker levels were consistent with higher turnover and bone loss in HIV-1 infected patients. FGF21 correlated negatively with BMD and BMC. FGF21 correlated positively with serum levels of osteoprotegerin and CTX-1, as well as with the CTX-1/osteocalcin ratio.Conclusions. Elevated FGF21 levels are associated with poor bone homeostasis in HIV-1-infected patients. Increases in FGF21 serum level may be an indicator not only of metabolic derangement but it may also serve as a biomarker of altered bone homeostasis in HIV-1 infected patients. (C) 2017 Elsevier Inc. All rights reserved.