AmpC β-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins
AmpC β-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins
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DOI：
10.1128/aac.48.10.4050-4053.2004
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发表时间：
2004-10-01
影响因子：
4.9
通讯作者：
Nordmann, P
中科院分区：
文献类型：
--
作者：
Mammeri, H;Nazic, H;Nordmann, P
克隆、测序和生化分析鉴定了一种新型AmpC型β-内酰胺酶，该酶在大肠杆菌临床分离株中赋予对超广谱头孢菌素的耐药性。该酶与E.大肠杆菌对头孢他啶和头孢吡肟有显著的水解作用。
Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephallosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.