Metabolite profiling of human blood by surface-enhanced Raman spectroscopy for surgery assessment and tumor screening in breast cancer
Metabolite profiling of human blood by surface-enhanced Raman spectroscopy for surgery assessment and tumor screening in breast cancer
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DOI：
10.1007/s00216-020-02391-4
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发表时间：
2020-01
影响因子：
4.3
通讯作者：
Duo Lin;Yunyi Wang;Tingyin Wang;Youzhi Zhu;Xueliang Lin;Yao Lin;S. Feng
中科院分区：
文献类型：
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作者：
Duo Lin;Yunyi Wang;Tingyin Wang;Youzhi Zhu;Xueliang Lin;Yao Lin;S. Feng
乳腺X线摄影是乳腺癌的标准筛查方法，可有效降低死亡率;然而，它存在频繁的假阳性警报和辐射风险。此外，手术治疗对乳腺癌的临床结果有着至关重要的影响，为乳腺癌的护理和管理提供了巨大的好处。在这项工作中，我们分析了乳腺癌患者的外周血样本与手术前后和健康志愿者使用无标记的表面增强拉曼光谱技术的基础上银纳米粒子。结果表明，可以对特定受试者的不同血液模式进行分析，并且通过多变量诊断算法，术前与术后以及术前与正常组的准确率分别达到95%和100%，为乳腺癌的手术评估以及肿瘤筛查提供了独特的血液分析方法。图形摘要
Mammography, a standard screening method for breast cancer, is effective for reducing the rate of death; however, it suffers from frequent false positive alarm and radiation risk. Besides, surgery treatment has a vital impact on the clinical outcomes of breast cancer, offering enormous benefits for breast cancer care and management. In this work, we analyzed the peripheral blood sample from breast cancer patients with pre- and post-surgery and healthy volunteers using label-free surface-enhanced Raman spectroscopy technology based on silver nanoparticles. Results showed that distinct patterns of blood belonging to specific subjects could be profiled, and corresponding accuracies of 95% and 100% were achieved by multivariate diagnostic algorithm for pre-surgery vs. post-surgery and pre-surgery vs. normal groups, respectively, providing a unique blood analysis method for surgery evaluation as well as tumor screening in breast cancer.Graphical abstract