Brown fat activity is not apparent in subjects with HIV lipodystrophy and increased resting energy expenditure.
Brown fat activity is not apparent in subjects with HIV lipodystrophy and increased resting energy expenditure.
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在患有艾滋病毒脂肪营养不良和静息能量消耗增加的受试者中，棕色脂肪活性并不明显。
DOI：
10.1038/oby.2011.231
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Bessesen,DanielH
中科院分区：
文献类型：
--
作者：
Kosmiski,LisaA;Sage-El,Adrienne;Kealey,ElizabethH;Bessesen,DanielH
HIV脂肪营养不良（LD）综合征与静息能量消耗（REE）增加有关，但这种高代谢的基础尚未确定。这项初步研究的目的是确定棕色脂肪是否在HIV LD和REE增加的受试者中被激活。在这项描述性研究中，4例HIV LD和明显高代谢受试者通过间接量热法测量REE，并通过18 F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）结合解剖计算机断层扫描（CT）确定棕色脂肪活性。棕色脂肪活性在HIV LD和静息高代谢的任何受试者中均不明显。因此，棕色脂肪激活不太可能是与HIV LD综合征相关的REE增加的主要原因。适应性产热的证据已被证明在这种综合征，但这项研究表明，组织以外的棕色脂肪组织（BAT）负责。进一步了解与HIV LD相关的慢性高代谢可以为能量平衡的调节提供新的见解。
The HIV lipodystrophy (LD) syndrome is associated with increased resting energy expenditure (REE), but the basis of this hypermetabolism has not been determined. The objective of this pilot study was to determine if brown fat is activated in subjects with HIV LD and increased REE. In this descriptive study of four subjects with HIV LD and marked hypermetabolism, REE was measured by indirect calorimetry and brown fat activity was determined by18F‐fluorodeoxyglucose (FDG) positron‐emission tomography (PET) combined with anatomic computed tomography (CT). Brown fat activity was not apparent in any subject with HIV LD and resting hypermetabolism. Therefore, brown fat activation is unlikely to be the principal cause of the increased REE associated with the HIV LD syndrome. Evidence of adaptive thermogenesis has been demonstrated in this syndrome, but this study suggests that tissues other than brown adipose tissue (BAT) are responsible. Further understanding of the chronic hypermetabolism associated with HIV LD could provide new insights into the regulation of energy balance.