Newborn screening for sickle cell disease in the Republic of Benin
Newborn screening for sickle cell disease in the Republic of Benin
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DOI：
10.1136/jcp.2008.059113
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发表时间：
2009-01-01
影响因子：
3.4
通讯作者：
Alihonou, E.
中科院分区：
文献类型：
--
作者：
Rahimy, M. C.;Gangbo, A.;Alihonou, E.
目的：制定一项新生儿镰状细胞病筛查战略，并将受影响的新生儿有效纳入适应非洲社会经济条件、卫生结构和文化背景的综合后续方案。在贝宁共和国经济首都科托努的两个最大的产科诊所实施的战略涉及一个经过专门培训的助产士小组，第一，确定有风险的孕妇，第二，向这些妇女提供积极和反复的信息和宣传，鼓励自愿要求新生儿筛查和参加后续方案。在连续研究的孕妇中，（约3 000人）中，79.5%的有胎儿SCD风险的知情妇女要求对其后代进行检测，85.2%的检测阳性新生儿参加了该方案，超过80%的患者5年后仍在接受随访。在这一系列的五岁以下儿童死亡率为15.5每10000人，这一数字是10倍，低于一般率记录在贝宁共和国。结论：结果表明，这种专门定制的战略是相关的这种设置，考虑到这个非洲国家的独特条件。
Aims: To develop a strategy for neonatal screening of sickle cell disease (SCD) and effective enrolment of affected neonates in a comprehensive follow-up programme adapted to the socioeconomic conditions, health structures and cultural background of an African setting.Methods: The strategy implemented at the two largest maternity services of Cotonou, the economic capital of the Republic of Benin, involves a team of specifically trained midwives, first to identify pregnant women at risk, and second to provide active and repeated information and sensitisation to these women to encourage voluntary demand for newborn screening and enrolment in the follow-up programme.Results: Among the consecutive pregnant women studied (about 3000), 79.5% of the informed women at risk for fetal SCD asked for testing of their offspring, 85.2% of the newborns who tested positive were enrolled in the programme, and more than 80% were still being followed up after 5 years. The under-five mortality rate in this series was 15.5 per 10000, a figure that is 10 times lower than the general rate recorded in the Republic of Benin.Conclusions: The results demonstrate that this specifically tailored strategy is relevant to this setting, given the unique conditions of this African country.