Epigenetic down regulation of nerve growth factor during alcohol withdrawal
Epigenetic down regulation of nerve growth factor during alcohol withdrawal
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DOI：
10.1111/j.1369-1600.2010.00307.x
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发表时间：
2013-05-01
影响因子：
3.4
通讯作者：
Hillemacher, Thomas
中科院分区：
文献类型：
--
作者：
Heberlein, Annemarie;Muschler, Marc;Hillemacher, Thomas
我们研究了酒精依赖患者（57名男性患者）在戒断期间（第1、7和14天）血液中神经生长因子（NGF）基因的胞嘧啶-磷脂酰-鸟嘌呤（CpG）岛启动子甲基化（平均值和单个CpG位点甲基化）。从第17天开始，甲基化和NGF血清水平没有显著变化。从第714天开始，平均甲基化增加（F=30.55，P
We investigated the Cytosin-phosphatidyl-Guanin (CpG) island promoter methylation (mean and methylation of individual CpG-sites) of the nerve growth factor (NGF) gene in the blood of alcohol-dependent patients (57 male patients) during withdrawal (days 1, 7 and 14). Methylation and NGF serum levels did not change significantly from days 17. From days 714, mean methylation increased (F=30.55, P