Changes in cerebral blood flow and recovery from acute stroke.
Changes in cerebral blood flow and recovery from acute stroke.
复制标题
脑血流量的变化和急性中风的恢复。
DOI：
10.1161/01.str.17.2.173
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发表时间：
1986
期刊：
影响因子：
8.3
通讯作者：
Reivich,M
中科院分区：
文献类型：
--
作者：
Burke,AM;Younkin,D;Gordon,J;Goldberg,H;Graham,T;Kushner,M;Obrist,W;Jaggi,J;Rosen,M;Reivich,M
我们前瞻性研究了14例急性脑梗死患者，采用系列133氙吸入脑血流测定（133 Xe-rCBF）、神经系统检查评分和神经心理学测试。所有患者在脑梗死后3天、1周、2周和4周接受相同的成套测试，以确定早期rCBF研究的预后价值以及rCBF变化与临床状态的时间关系。急性卒中症状出现3天内的基线rCBF与临床神经学结局无关（对于所用的两个rCBF指标，r =-0.17，p <0.30; r =-0.18，p <0.28）。在11例显示神经功能恢复的患者中，7例在1周时改善，在rCBF增加之前显著改善（p <0.05）。我们的结论是，早期基线rCBF不能预测急性脑梗死患者的临床结局，神经功能恢复先于rCBF增加，而不是rCBF增加。
We prospectively studied 14 patients with acute cerebral infarctions using serial 133Xenon inhalation cerebral determination (133Xe-rCBF), scored neurological examinations, and neuropsychological testing. All patients underwent the same battery of tests at 3 days, 1 week, 2 weeks, and 4 weeks after cerebral infarction to determine the prognostic value of early rCBF studies and the chronological relationship of changes in rCBF to clinical status. Baseline rCBF within 3 days of symptoms of acute stroke did not correlate with clinical neurological outcome (r = -0.17, p less than 0.30; r = -0.18, p less than 0.28, for the two indices of rCBF used). Among the 11 patients demonstrating neurological recovery, 7 improved at 1 week, significantly before increases in rCBF (p less than 0.05). We conclude that early baseline rCBF does not predict clinical outcome in patients with acute cerebral infarctions and that return of neurological function precedes rather than follows increases in rCBF.