Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation Does proteoglycan 4 have the ability to buffer the inflammatory response?
Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation Does proteoglycan 4 have the ability to buffer the inflammatory response?
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DOI：
10.1002/bies.201800166
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发表时间：
2019-01-01
期刊：
影响因子：
4
通讯作者：
Dufour, Antoine
中科院分区：
文献类型：
--
作者：
Das, Nabangshu;Schmidt, Tannin A.;Dufour, Antoine
蛋白聚糖4（PRG4），首先在滑液中鉴定，是关节中的细胞外基质结构蛋白，涉及减少软骨表面的剪切以及控制粘附依赖性滑膜生长和调节大量蛋白质沉积到软骨上。然而，最近的证据表明，它可以结合并影响下游信号的细胞表面受体参与调节炎症反应。因此，我们提出假设：PRG4是否调节炎症反应并维持组织稳态？基于这些新的发现，涉及PRG4作为一种炎症信号分子，我们将提出并讨论几个假设的潜在机制，PRG4可能能够调节炎症。如果未来的研究能够证明PRG4是一种有效的炎症介质，这将改变肌肉骨骼和眼科领域目前关于炎症微环境如何在这些组织和其他组织中调节的范式。
Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion-dependent synovial growth and regulating bulk protein deposition onto the cartilage. However, recent evidence suggests that it can bind to and effect downstream signaling of a number of cell surface receptors implicated in regulating the inflammatory response. Therefore, we pose the hypothesis: Does PRG4 regulate the inflammatory response and maintain tissue homeostasis? Based on these novel findings implicating PRG4 as an inflammatory signaling molecule, we will present and discuss several hypotheses regarding potential mechanisms by which PRG4 may be able to regulate inflammation. If future studies can demonstrate that PRG4 is a potent inflammatory mediator, this will change current paradigms in the musculoskeletal and ophthalmological fields regarding the how the inflammatory microenvironment is regulated in these tissues and potentially others.