Hemidesmosomes: Roles in adhesion, signaling and human diseases
Hemidesmosomes: Roles in adhesion, signaling and human diseases
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DOI：
10.1016/s0955-0674(96)80106-2
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发表时间：
1996-10-01
影响因子：
7.5
通讯作者：
Sonnenberg, A
中科院分区：
文献类型：
--
作者：
Borradori, L;Sonnenberg, A
通过靶向基因突变实验和对几种已证实半桥粒蛋白缺失或缺陷的皮肤起泡疾病的观察，我们对半桥粒在细胞-基质粘附中的作用的理解已大大提高。最近通过转染和诱变研究鉴定了构成半桥粒的蛋白质内的重要功能域。这些多蛋白复合物似乎不仅介导细胞粘附，而且还将信号从细胞外基质转导到细胞内部，从而可能深刻地调节细胞行为。
Our understanding of the role of hemidesmosomes in cell-substratum adhesion has greatly improved both as a result of targeted gene mutation experiments and by means of observations of several blistering disorders of the skin in which the absence or defects of hemidesmosomal proteins have been demonstrated. Functionally important domains within the proteins that constitute hemidesmosomes have recently been identified by transfection and mutagenesis studies. These multiprotein complexes appear not only to mediate cell adhesion, but also to transduce signals from the extracellular matrix to the cell interior that may profoundly modulate cell behavior.