Retinoic acid synthesis for the developing telencephalon.
Retinoic acid synthesis for the developing telencephalon.
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DOI：
10.1093/cercor/11.10.894
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发表时间：
2001-10
期刊：
影响因子：
3.7
通讯作者：
D. Smith;E. Wagner;O. Koul;P. McCaffery;U. C. Dräger
中科院分区：
文献类型：
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作者：
D. Smith;E. Wagner;O. Koul;P. McCaffery;U. C. Dräger
众所周知，小脂维甲酸在体外可以促进神经元分化，并在胚胎大脑中起到致畸剂的作用，但关于内源性合成的维甲酸在前脑发育中的自然作用，人们知之甚少。维甲酸主要由三种视黄醛脱氢酶合成。我们在这里展示了发育中的端脑的视黄醛脱氢酶在哪里表达，以及它们的表达模式如何随着发育时间的变化而变化。从视黄醛脱氢酶部位扩散出来的维甲酸可能会影响神经发生开始之前的早期端脑，以及神经元的分化和向大脑皮层的放射状迁移。由于其可扩散的特性，维甲酸是一种独特的工具，用于协调发育中的端脑在中等距离范围内的生长过程。
The small lipid retinoic acid is known to promote neuronal differentiation in vitro and to act as a teratogen in the embryonic brain, but very little is known about the natural role of endogenously synthesized retinoic acid in forebrain development. Retinoic acid is synthesized mainly by three retinaldehyde dehydrogenases. We show here where the retinaldehyde dehydrogenases for the developing telencephalon are expressed and how their expression patterns change over developmental time. Retinoic acid diffusing from the retinaldehyde dehydrogenase sites is likely to influence the early telencephalon before the beginning of neurogenesis, as well as differentiation and radial migration of neurons into the cerebral cortex. Because of its diffusible character, retinoic acid represents a unique tool for the coordination of growth processes over an intermediate distance range in the developing telencephalon.