Primary Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways.
Primary Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways.
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DOI：
10.3390/cells10061428
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发表时间：
2021-06-08
期刊：
影响因子：
6
通讯作者：
Pugacheva EN
中科院分区：
文献类型：
--
作者：
Yanardag S;Pugacheva EN
信号网络在干细胞的谱系特化和终末分化过程中指导干细胞。初级纤毛是一种触角状突起，直接或间接地在这种引导中起着重要作用。到目前为止，所有表征的干细胞都具有初级纤毛。它们通过控制信号转导和稳定性作为各种信号事件的入口或检查点。因此，初级纤毛形成或动力学的缺陷引起发育和健康问题，包括但不限于肥胖、心血管和肾异常、听力和视力丧失，甚至癌症。在这篇综述中，我们重点介绍了最近的研究结果，初级纤毛如何控制各种信号通路在干细胞分化，并确定在该领域的未来研究的潜在差距。
Signaling networks guide stem cells during their lineage specification and terminal differentiation. Primary cilium, an antenna-like protrusion, directly or indirectly plays a significant role in this guidance. All stem cells characterized so far have primary cilia. They serve as entry- or check-points for various signaling events by controlling the signal transduction and stability. Thus, defects in the primary cilia formation or dynamics cause developmental and health problems, including but not limited to obesity, cardiovascular and renal anomalies, hearing and vision loss, and even cancers. In this review, we focus on the recent findings of how primary cilium controls various signaling pathways during stem cell differentiation and identify potential gaps in the field for future research.
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影响因子：
3.9
作者：
Chippalkatti R;Abankwa D
通讯作者：
Abankwa D
影响因子：
3.6
作者：
Bae, Yun Kyung;Kim, Gee-Hye;Jin, Hye Jin
通讯作者：
Jin, Hye Jin
影响因子：
3.7
作者：
Abel EV;Kim EJ;Wu J;Hynes M;Bednar F;Proctor E;Wang L;Dziubinski ML;Simeone DM
通讯作者：
Simeone DM
对纤毛的横截面的重新研究。
影响因子：
7.8
作者：
Allen, R D
通讯作者：
Allen, R D
初级纤毛通过 Lkb1 调节 mTORC1 活性和细胞大小。
影响因子：
21.3
作者：
Boehlke, Christopher;Kotsis, Fruzsina;Patel, Vishal;Braeg, Simone;Voelker, Henriette;Bredt, Saskia;Beyer, Theresa;Janusch, Heike;Hamann, Christoph;Goedel, Markus;Mueller, Klaus;Herbst, Martin;Hornung, Miriam;Doerken, Mara;Koettgen, Michael;Nitschke, Roland;Igarashi, Peter;Walz, Gerd;Kuehn, E. Wolfgang
通讯作者：
Kuehn, E. Wolfgang