Surgical results in patients with dual hepatitis B- and C-related hepatocellular carcinoma compared with hepatitis B- or C-related hepatocellular carcinoma
Surgical results in patients with dual hepatitis B- and C-related hepatocellular carcinoma compared with hepatitis B- or C-related hepatocellular carcinoma
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DOI：
10.1067/msy.1998.87237
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发表时间：
1998-05-01
期刊：
影响因子：
3.8
通讯作者：
Chen, TC
中科院分区：
文献类型：
--
作者：
Chen, MF;Jeng, LB;Chen, TC
背景。本研究的目的是报道肝细胞癌（HCC）合并乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）双重感染患者的手术结果，并评估这些患者与乙型肝炎或丙型肝炎相关HCC患者手术结果的差异。比较1991 ~ 1995年行肝切除术的13例乙型肝炎表面抗原（HBsAg）阳性和丙型肝炎抗体（HCV Ab）阳性患者（BC-HCC组）、57例HBsAg阳性和HCV Ab阴性患者（B- hcc组）和34例HBsAg阴性和HCV空气阳性患者（C- hcc组）的手术结果。BC-HCC患者术后一个月内手术死亡率为7.7%。与B-HCC和C-HCC患者相比，差异无统计学意义（分别为5.3%和5.9%）。BC-HCC患者术后出现肝功能衰竭、术后腹水和伤口感染各1例。此外，组间差异无统计学意义（BC-HCC、B-HCC和C-HCC患者分别为23.1%、22.8%和20.5%）。在该系列中，BC-HCC患者的1、3、5年生存率分别为75%、50%和40%。术后复发率为66.7%。不同组间病毒相关性HCC的总生存率和无病生存率无统计学差异。HBV和HCV双重感染的HCC患者行肝切除术的手术发病率和死亡率略高，但与乙型或丙型肝炎相关的HCC相比，生存率和复发率没有统计学差异。
Background. The purpose of our study was to report on the surgical outcomes of patients with hepatocellular carcinoma (HCC) with dual hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and to assess the differences in the surgical results between those patients and the patients with hepatitis B-or hepatitis C-related HCC.Methods. The operative outcomes of 13 patients with hepatitis B surface antigen (HBsAg)-positive and hepatitis C antibody (HCV Ab)-positive (the BC-HCC group) results, 57 patients with HBsAg-positive and HCV Ab-negative (the B-HCC group) results, and 34 patients with HBsAg-negative and HCV Air-positive (the C-HCC group) results, who had undergone hepatic resection from 1991 to 1995, were compared.Results. The operative mortality rate within month after operation for patients with BC-HCC was 7.7 %. No statistically significant difference was found compared with the patients with B-HCC and C-HCC (5.3 % and 5.9 %, respectively). The postoperative course of patients with BC-HCC was complicated by liver failure, postoperative ascites, and wound infection in one patient each. Also, no statistically significant difference was found among the groups (23.1 %, 22.8 %, and 20.5 % for patients with BC-HCC, B-HCC, and C-HCC, respectively). The overall 1-, 3-, and 5-year survival rates of patients with BC-HCC in this series were 75 %, 50 %, and 40 %, respectively. The postoperative recurrence rate was 66.7 %. No statistically significant differences were found between the various groups of the virus-related HCC on the overall survival rate and disease-free survival rate.Conclusions. Hepatic resection for HCC in patients with dual HBV and HCV infections was associated with slightly higher operative morbidity and mortality rates, but there were no statistical differences compared with hepatitis B- or C-related HCC regarding the survival and recurrence rates.