MIDBRAIN MICROINFUSIONS OF PROLACTIN INCREASE THE ESTROGEN-DEPENDENT BEHAVIOR, LORDOSIS
MIDBRAIN MICROINFUSIONS OF PROLACTIN INCREASE THE ESTROGEN-DEPENDENT BEHAVIOR, LORDOSIS
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DOI：
10.1126/science.6828874
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
PFAFF, DW
中科院分区：
文献类型：
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作者：
HARLAN, RE;SHIVERS, BD;PFAFF, DW
将大鼠催乳素微量输注到经过雌激素处理的卵巢切除大鼠的背侧中脑中，可增加脊柱前凸行为。将催乳素抗血清微量输注到表现出最大脊柱前凸的大鼠的中脑，会产生相反的效果。通过免疫细胞化学研究了催乳素样物质在大脑中的分布。投射到中脑的下丘脑神经元系统含有一种类似催乳素的物质，它在促进这种行为方面发挥着作用，因此可能介导雌激素对大脑的一些影响。这些数据与催乳素基因及其调控研究的其他数据一起表明，分析大脑中促进行为反应的一系列分子事件是可能的。
Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. A hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.