Rheometrical detection of incipient blood clot formation by Fourier transform mechanical spectroscopy
Rheometrical detection of incipient blood clot formation by Fourier transform mechanical spectroscopy
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DOI：
10.1016/j.jnnfm.2007.04.020
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发表时间：
2008-01-17
影响因子：
3.1
通讯作者：
Williams, R. L.
中科院分区：
文献类型：
--
作者：
Evans, P. A.;Hawkins, K.;Williams, R. L.
本文报道了用振荡剪切傅里叶变换力学谱研究全血的凝固。结果包括第一次确定的凝胶点的血液中的Chambon-Winter凝胶点的标准，我们展示了如何这可能被用来作为一个适当的基础，用于检测建立一个初期凝块的样本中的人血。该技术与从血栓弹性描记器（TEG）获得的结果的比较表明，后者不能够检测初始凝块，其建立可以发生在第一次记录TEG响应之前几分钟。我们的研究结果还揭示了，第一次，早期凝块的分形特征。对从健康个体抽取的全血样本在凝胶点处获得的粘弹数据的分析表明，初始凝块的特征在于分形维d（f）= 1.74（+/- 0.07）。这些研究结果的意义进行了讨论，在其潜在的应用研究中的病理引起的血液凝块微观结构的变化。(c)2007 Elsevier B. V.保留所有权利。
We report a study of the coagulation of whole blood by oscillatory shear Fourier transform mechanical spectroscopy. The results include the first identification of the Gel Point of coagulating blood in terms of the Chambon-Winter Gel Point criterion and we show how this may be used as an appropriate basis for detecting the establishment of an incipient clot in samples of human blood. A comparison of this technique with results obtained from a thromboelastograph (TEG) indicate that the latter is not capable of detecting the incipient clot, whose establishment can occur several minutes prior to the first recorded TEG response. Our results also reveal, for the first time, the incipient clot's fractal characteristics. An analysis of the viscoelastic data obtained at the Gel Point of samples of whole blood drawn from healthy individuals indicate that the incipient clot is characterised by a fractal dimension d(f) = 1.74( +/- 0.07). The significance of these findings is discussed in terms of their potential application in studies of pathologically induced changes in blood clot microstructure. (c) 2007 Elsevier B.V. All rights reserved.