Endoplasmic reticulum architecture: structures in flux
Endoplasmic reticulum architecture: structures in flux
复制标题
DOI：
10.1016/j.ceb.2006.06.008
复制
发表时间：
2006-08-01
影响因子：
7.5
通讯作者：
Snapp, Erik
中科院分区：
文献类型：
--
作者：
Borgese, Nica;Francolini, Maura;Snapp, Erik
内质网（ER）是一个动态的多形细胞器，包含连续但不同的亚结构域。ER结构的多样性与其许多功能相似，包括分泌蛋白生物合成、脂质合成、药物代谢和Ca 2+信号传导。最近的研究揭示了如何精心的ER结构出现在蛋白质水平，动力学和相互作用的微妙变化，以及在细胞溶质离子浓度的变化。子域的形成似乎是由自组织的原则。一旦形成，ER亚结构域保持可塑性，并且可以响应于改变的条件而迅速转化为替代结构。调节ER结构的机制可能对其他细胞器的特征形状的产生很重要。
The endoplasmic reticulum (ER) is a dynamic pleiomorphic organelle containing continuous but distinct subdomains. The diversity of ER structures parallels its many functions, including secretory protein biogenesis, lipid synthesis, drug metabolism and Ca2+ signaling. Recent studies are revealing how elaborate ER structures arise in response to subtle changes in protein levels, dynamics, and interactions as well as in response to alterations in cytosolic ion concentrations. Subdomain formation appears to be governed by principles of self-organization. Once formed, ER subdomains remain malleable and can be rapidly transformed into alternative structures in response to altered conditions. The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles.