The growth of acute kidney injury: a rising tide or just closer attention to detail?

The growth of acute kidney injury: a rising tide or just closer attention to detail?
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DOI:
10.1038/ki.2014.293
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发表时间:
2015-01
影响因子:
19.6
通讯作者:
--
中科院分区:
医学1区
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--
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急性肾损伤(AKI),以前称为急性肾功能衰竭,与死亡率增加、住院时间延长和慢性肾脏疾病(CKD)加速有关。在过去的20年里,AKI的发病率急剧上升,尤其是在美国。问题是,这些变化是否反映了疾病发病率的实际增加,或者可能是由于采用了依赖于血清肌酐的微小标准化变化的共识定义、编码和报销的变化、或越来越多的可获得和更自由地使用透析来解释的。在这篇综述中,我们探讨了北美和西欧AKI发病率的长期趋势及其潜在的影响因素。
Acute kidney injury (AKI), previously termed acute renal failure, is associated with increased mortality, prolonged hospital stay, and accelerated chronic kidney disease (CKD). Over the past 2 decades, dramatic rises in the incidences of AKI have been reported, particularly within the United States. The question arises as to whether these changes reflect actual increases in disease incidence, or are potentially explained by the introduction of consensus definitions that rely on small standardized changes in serum creatinine, changes in coding and reimbursement, or increasingly available and more liberal use of dialysis. In this review, we explore the secular trends in AKI incidence in North America and Western Europe and its potential contributors.
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