Hyper-polyploid embryos survive after implantation in mice
Hyper-polyploid embryos survive after implantation in mice
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DOI：
10.1017/s0967199420000064
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发表时间：
2020-03
期刊：
影响因子：
1.7
通讯作者：
Hiroyuki Imai;T. Iwamori;K. Kusakabe;Y. Kiso;E. Ono;K. Kano
中科院分区：
文献类型：
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作者：
Hiroyuki Imai;T. Iwamori;K. Kusakabe;Y. Kiso;E. Ono;K. Kano
由自然全基因组复制产生的多倍体在脊椎动物进化中起着动力作用。作为进化的证据，多倍体生物普遍存在，但在哺乳动物中还没有多倍体生物的报道。在小鼠中，多倍体胚胎在正常培养条件下通常发育到胚泡阶段。然而，大多数四倍体胚胎在植入后退化，表明全基因组复制对小鼠的正常发育产生有害影响。以前对多倍体的研究主要集中在四倍体胚胎上。分析各种倍性结果对于理解多倍化对胚胎发育的影响是重要的。本研究旨在探讨多倍体化对着床后胚胎着床和发育的影响程度。本文首次描述了一个八倍体胚胎植入小鼠，尽管超多倍化，并表明这些哺乳动物胚胎有能力植入，甚至发展，尽管极端的全基因组复制的危害。
Summary Polyploids generated by natural whole genome duplication have served as a dynamic force in vertebrate evolution. As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture conditions normally develop to the blastocyst stage. Nevertheless, most tetraploid embryos degenerate after implantation, indicating that whole genome duplication produces harmful effects on normal development in mice. Most previous research on polyploidy has mainly focused on tetraploid embryos. Analysis of various ploidy outcomes is important to comprehend the effects of polyploidization on embryo development. The purpose of this present study was to discover the extent of the polyploidization effect on implantation and development in post-implantation embryos. This paper describes for the first time an octaploid embryo implanted in mice despite hyper-polyploidization, and indicates that these mammalian embryos have the ability to implant, and even develop, despite the harmfulness of extreme whole genome duplication.