Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS
Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS
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DOI：
10.1152/jappl.1999.87.6.2068
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发表时间：
1999-12-01
影响因子：
3.3
通讯作者：
Bell, JD
中科院分区：
文献类型：
--
作者：
Rico-Sanz, J;Thomas, EL;Bell, JD
我们使用 H-1 磁共振波谱法无创测定三种人体骨骼肌中的总肌酸 (TCr)、含胆碱化合物 (Cho) 以及细胞内 (IT) 和细胞外（肌纤维间）甘油三酯 (ET)。受试者（n = 15 名男性）比目鱼肌中的 TCr 浓度 [Sol; 100.2 +/- 8.3 (SE) mmol/kg 干重]低于腓肠肌（胃；125.3 +/- 9.2 mmol/kg 干重）和胫骨前肌（TA；123.7 +/- 8.8 mmol/kg 干重）。与 TA（13.6 +/- 2.4 mmol/kg 干重）相比，Sol（35.8 +/- 3.6 mmol/kg 干重）和 Gast（28.5 +/- 3.5 mmol/kg 干重）中的 Cho 水平较高（分别为 P < 0.001 和 P < 0.01）。 Sol 和 Gast 中的 IT 值分别为 44.8 +/- 4.6 和 36.5 +/- 4.2 mmol/kg 干重。TA 的 IT 值（24.6 +/- 4.5 mmol/kg 干重）低于 Sol (P < 0.01) 和 Gast (P < 0.05)。 ET 没有差异[116.0 +/- 11.2 (Sol)、119.1 +/- 18.5 (Gast) 和 91.4 +/- 19.2 mmol/kg 干重 (TA)]。提出代谢物水平的差异可能是由于不同肌肉在运动过程中的适应导致纤维类型组成和代谢物沉积的差异所致。
We used H-1-magnetic resonance spectroscopy to noninvasively determine total creatine (TCr), choline-containing compounds (Cho), and intracellular (IT) and extracellular (between;muscle fibers) triglycerides (ET) in three human skeletal muscles. Subjects' (n = 15 men) TCr concentrations in soleus [Sol; 100.2 +/- 8.3 (SE) mmol/kg dry wt] were lower (P < 0.05) than those in gastrocnemius (Gast; 125.3 +/- 9.2 mmol/kg dry wt) and tibialis anterior (TA; 123.7 +/- 8.8 mmol/kg dry wt). The Cho levels in Sol (35.8 +/- 3.6 mmol/kg dry wt) and Gast (28.5 +/- 3.5 mmol/kg dry wt) were higher (P < 0.001 and P < 0.01, respectively) compared with TA (13.6 +/- 2.4 mmol/kg dry wt). The IT values were found to be 44.8 +/- 4.6 and 36.5 +/- 4.2 mmol/kg dry wt in Sol and Gast, respectively The IT values of TA (24.6 +/- 4.5 mmol/kg dry wt) were lower than those of Sol (P < 0.01) and Gast (P < 0.05). There were no differences in ET [116.0 +/- 11.2 (Sol), 119.1 +/- 18.5 (Gast), and 91.4 +/- 19.2 mmol/kg dry wt (TA)]. It is proposed that the differences in metabolite levels may be due to the differences in fiber-type composition and deposition of metabolites due to the adaptation of different muscles during locomotion.