Age-Specific Average Head Template for Typically Developing 6-Month-Old Infants
Age-Specific Average Head Template for Typically Developing 6-Month-Old Infants
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DOI：
10.1371/journal.pone.0073821
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发表时间：
2013-09-12
期刊：
影响因子：
3.7
通讯作者：
Kuhl, Patricia K.
中科院分区：
文献类型：
--
作者：
Akiyama, Lisa F.;Richards, Todd R.;Kuhl, Patricia K.
由于人类早期发育中大脑结构发生的快速解剖变化以及婴儿大脑与广泛使用的标准成人模板之间的显着差异，在分析婴儿神经成像数据时利用适当的年龄和人群特定平均模板变得越来越重要。在这项研究中，我们通过对60名受试者的结构图像进行线性归一化、同构归一化和迭代平均处理，在标准的MNI 152样婴儿坐标系中为健康的、通常发育中的6个月大的婴儿创建了一个新的、高度详细的年龄特异性无偏平均头部模板。与现有的婴儿平均模板相比，在标准的MNI 152样婴儿坐标系中得到的特定年龄的平均模板展示了更清晰的解剖细节和清晰度，并成功地保留了6个月大婴儿的平均头部尺寸。平均婴儿模板的示例使用将脑磁图（MEG）估计的活动位置从MEG的受试者特定头部坐标空间变换到标准MNI 152样婴儿坐标空间。我们还创建了一个新的图谱，反映了真实的6个月大的婴儿大脑解剖结构。平均模板和地图集可在我们的网站（http：//ilabs.washington.edu/6-m-templates-atlas）上公开获取。
Due to the rapid anatomical changes that occur within the brain structure in early human development and the significant differences between infant brains and the widely used standard adult templates, it becomes increasingly important to utilize appropriate age- and population-specific average templates when analyzing infant neuroimaging data. In this study we created a new and highly detailed age-specific unbiased average head template in a standard MNI152-like infant coordinate system for healthy, typically developing 6-month-old infants by performing linear normalization, diffeomorphic normalization and iterative averaging processing on 60 subjects' structural images. The resulting age-specific average templates in a standard MNI152-like infant coordinate system demonstrate sharper anatomical detail and clarity compared to existing infant average templates and successfully retains the average head size of the 6-month-old infant. An example usage of the average infant templates transforms magnetoencephalography (MEG) estimated activity locations from MEG's subject-specific head coordinate space to the standard MNI152-like infant coordinate space. We also created a new atlas that reflects the true 6- month-old infant brain anatomy. Average templates and atlas are publicly available on our website (http://ilabs.washington.edu/6-m-templates-atlas).