A spiral attractor network drives rhythmic locomotion
A spiral attractor network drives rhythmic locomotion
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DOI：
10.7554/elife.27342
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发表时间：
2017-08-07
期刊：
影响因子：
7.7
通讯作者：
Humphries, Mark D.
中科院分区：
文献类型：
--
作者：
Brunolt, Angela M.;Frost, William N.;Humphries, Mark D.
神经群的联合活动是高维的、复杂的。要想对电路功能有一个易于理解的理解，一个策略是寻找能够解释种群活动的最简单的动力系统。在模拟运动过程中，通过对海兔脚神经节的成像，我们发现海兔整个种群的活动是由一个低维螺旋吸引子引起的。唤起运动使种群进入一个低维的、周期性的、衰减的轨道——一个螺旋——在这个轨道上，它表现得像一个真正的吸引子，在被唤起时收敛到同一个轨道上，在短暂的扰动之后又回到那个轨道上。我们发现在每一个准备中都有相同的吸引子，并且可以直接从其轨道预测运动输出，然而单个神经元的参与在连续的运动回合中发生了变化。根据这些结果，我们提出只有运动控制的低维动态，而不是高维群体活动，在神经系统内部和之间是一致的。
The joint activity of neural populations is high dimensional and complex. One strategy for reaching a tractable understanding of circuit function is to seek the simplest dynamical system that can account for the population activity. By imaging Aplysia's pedal ganglion during fictive locomotion, here we show that its population-wide activity arises from a low-dimensional spiral attractor. Evoking locomotion moved the population into a low-dimensional, periodic, decaying orbit - a spiral - in which it behaved as a true attractor, converging to the same orbit when evoked, and returning to that orbit after transient perturbation. We found the same attractor in every preparation, and could predict motor output directly from its orbit, yet individual neurons' participation changed across consecutive locomotion bouts. From these results, we propose that only the low-dimensional dynamics for movement control, and not the high-dimensional population activity, are consistent within and between nervous systems.