The relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) of neon ions for the EMT6 tumor system.
The relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) of neon ions for the EMT6 tumor system.
复制标题
氖离子对 EMT6 肿瘤系统的相对生物有效性 (RBE) 和氧增强比 (OER)。
DOI：
10.1148/120.2.439
复制
发表时间：
1976
期刊：
影响因子：
19.7
通讯作者：
T. Phillips
中科院分区：
文献类型：
--
作者：
K. Fu;T. Phillips
在体内和体外，在射束的平台和展开的Bragg峰区，对EMT6肿瘤进行了照射。体内相对生物利用度高原地区为1.7~2.1，布拉格峰为2.6~2.9，OER分别为2.0和1.4。由于霓离子在组织中具有较低的OER和良好的深度剂量分布，因此在肿瘤的放射治疗中具有巨大的潜力。
EMT6 tumors were exposed to neon ions in vivo and in vitro in the plateau and spread-out Bragg peak regions of the beam. The RBE in vivo was 1.7-2.1 in the plateau region and 2.6-2.9 in the Bragg peak; the OER was 2.0 and 1.4, respectively. Neon ions have great potential in the radiotherapy of tumors because of their decreased OER and excellent depth-dose distribution in tissue.