Image-based morphometric studies of human coronary artery bifurcations with/without coronary artery disease
Image-based morphometric studies of human coronary artery bifurcations with/without coronary artery disease
复制标题
对患有/不患有冠状动脉疾病的人冠状动脉分叉进行基于图像的形态测量研究
DOI：
10.1080/10255842.2020.1850702
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发表时间：
2020-11-18
影响因子：
1.6
通讯作者：
Wu，Jianhua
中科院分区：
文献类型：
--
作者：
Chen，Xueping;Dai，Jingxing;Wu，Jianhua
研究冠状动脉分叉部形态计量学特征变化与冠状动脉病变的关系具有重要的临床意义。本研究的目的是确定与非CAD受试者相比，CAD病变患者的形态学变化，并找到可用于心血管疾病诊断的指标。采用中国南方人群的CT血管造影图像重建冠状动脉树。默里定律被引入到评估现实的血管网络从其最佳状态的偏差的水平。结果显示，CAD左侧的偏差值（和）最高，而非CAD右侧的偏差值（分别为和）最低。此外，非CAD左侧、CAD左侧、非CAD右侧和CAD右侧的与之间的比值的斜率值分别为0.7428、0.7004、0.7628和0.7577。理论上，当分叉结构处于最优状态时，斜率值应等于1。因此，这些结果表明，有CAD病变的冠状动脉分叉比无CAD病变的冠状动脉分叉偏离最佳结构更远，并且右侧冠状动脉分叉比左侧冠状动脉分叉更接近最佳结构。更重要的是，本研究发现，和只依赖于疾病状态，而不是年龄，这表明和有可能作为两个新的指标，早期冠心病的诊断。
It is of great clinical significance to study the relationship between coronary bifurcation’s morphometrical feature change and coronary artery disease (CAD) lesion. The purpose of this study is to determine the morphological changes in patients with CAD lesion when compared with non-CAD subjects and to find indicators that may be used for cardiovascular disease diagnosis. Computed tomography angiography images from Southern Chinese populations were used to reconstruct three-dimensional coronary arterial trees. Murray's law was introduced to assess the level of deviation of the realistic vascular networks from their optimal state. The results showed CAD Left had the highest deviation values of(and(), while non-CAD Right had the lowest values (andrespectively). Moreover, the slope values of the ratio betweenandfor non-CAD Left, CAD Left, non-CAD Right, and CAD Right were 0.7428, 0.7004, 0.7628, and 0.7577, respectively. Theoretically, the slope value should equal to 1 when the bifurcation structure is in its optimal state. Therefore, these results indicated that coronary bifurcations with CAD lesion deviated from the optimal structure further than those without CAD lesion and coronary bifurcations in right were closer to the optimal structure than those in left. More importantly, the present study found thatanddepended only on the diseased state, but not age, suggesting thatandwere potentially used as two novel indicators for early CAD diagnosis.