Adverse effects of ultraviolet radiation: A brief review
Adverse effects of ultraviolet radiation: A brief review
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DOI：
10.1016/j.pbiomolbio.2006.02.011
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发表时间：
2006-09-01
影响因子：
3.8
通讯作者：
Lee, Tim K.
中科院分区：
文献类型：
--
作者：
Gallagher, Richard P.;Lee, Tim K.
太阳紫外线辐射（UVR）一直是人类环境的一部分。UVB是7-脱氧胆固醇转化为维生素D所必需的，这对维持健康至关重要，研究表明它在维持人类健康方面具有其他潜在作用。暴露于紫外线辐射，无论是太阳辐射还是人造辐射，都对人类健康构成潜在风险。紫外线辐射是一种已知的致癌物质，过度的紫外线辐射（至少是对阳光中的太阳辐射）会增加患唇癌、皮肤基底细胞癌和鳞状细胞癌以及皮肤黑色素瘤的风险，特别是在白皙皮肤人群中。也有证据表明，太阳紫外线辐射增加了几种眼睛疾病的风险，包括皮质性白内障，一些结膜肿瘤，可能还有眼黑色素瘤。太阳紫外线辐射也可能与自身免疫性疾病和病毒性疾病有关，尽管在这些领域还需要更多的研究。人工紫外线辐射来自晒黑床、焊枪和其他来源，这篇简短的综述将评估太阳和人造紫外线辐射对人类健康不利影响的证据，并试图确定这一主要疾病的确切程度-基于现有科学证据的权重的暴露关系。(c)2006爱思唯尔有限公司保留所有权利。
Solar ultraviolet radiation (UVR) has always been part of the environment of man. UVB is required for the conversion of 7-deoxycholesterol to vitamin D, which is critically important in the maintenance of healthy holies and research is making clear that it has other potential roles in maintenance of human health. Exposure to UVR, whether of solar or artificial origin, also carries potential risks to human health. UVR is a known carcinogen and excessive exposure-at least to solar radiation in sunlight-increases risk of cancer of the lip, basal cell, and squamous cell carcinoma of the skin and cutaneous melanoma, particularly in fair skin populations. There is also evidence that solar UVR increases risk of several diseases of the eye, including cortical cataract, some conjunctival neoplasms, and perhaps ocular melanoma. Solar UVR may also be involved in autoimmune and viral diseases although more research is needed in these areas.Artificial UVR from tanning beds, welding torches, and other sources, may contribute to the burden of disease from UVR.This brief review will assess the human evidence for adverse health effects from solar and artificial UVR and will attempt to assign a degree of certainty to the major disease-exposure relationships based on the weight of available scientific evidence. (c) 2006 Elsevier Ltd. All rights reserved.