Silver nanoparticle gated, mesoporous silica coated gold nanorods (AuNR@MS@AgNPs): low premature release and multifunctional cancer theranostic platform.
Silver nanoparticle gated, mesoporous silica coated gold nanorods (AuNR@MS@AgNPs): low premature release and multifunctional cancer theranostic platform.
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DOI：
10.1021/acsami.5b00368
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发表时间：
2015-03
影响因子：
9.5
通讯作者：
Zhehua Zhang;Changhui Liu;Junhui Bai;Cuichen Wu;Yue Xiao;Yinhui Li;Jing Zheng;Ronghua Yang
中科院分区：
文献类型：
--
作者：
Zhehua Zhang;Changhui Liu;Junhui Bai;Cuichen Wu;Yue Xiao;Yinhui Li;Jing Zheng;Ronghua Yang
与成像模块和治疗药物集成的多功能纳米颗粒是未来癌症诊断和治疗的有希望的候选者。介孔二氧化硅包覆的金纳米棒（AuNR@MS）已经成为一种新型的多功能癌症治疗诊断平台，其结合了介孔二氧化硅的大比表面积（这保证了高药物有效载荷）和AuNR的光热模态。然而，过早释放和外源性刺激的副作用仍然阻碍了AuNR@ MS的进一步应用。为了解决这些问题，本文中，我们提出了一种谷胱甘肽（GSH）响应性多功能AuNR@MS纳米载体与原位形成的银纳米颗粒（AgNPs）作为封端剂。内部的AuNR核用作热疗剂，而外部的介孔二氧化硅壳表现出允许高药物有效载荷的潜力，从而将其本身作为有效的药物载体。随着靶向适体的掺入，所构建的纳米载体显示出根据细胞内GSH水平的药物释放，其中最大药物释放到肿瘤中并且最小全身释放到血液中。同时，光热效应的AuNR应用于近红外（NIR）光导致的局部温度迅速上升，导致增强的细胞毒性。AuNR@MS@AgNPs这样的多功能治疗诊断系统有望具有广泛的生物医学应用，并且可能特别适用于癌症治疗。
Multifunctional nanoparticles integrated with an imaging module and therapeutic drugs are promising candidates for future cancer diagnosis and therapy. Mesoporous silica coated gold nanorods (AuNR@MS) have emerged as a novel multifunctional cancer theranostic platform combining the large specific surface area of mesoporous silica, which guarantees a high drug payload, and the photothermal modality of AuNRs. However, premature release and side effects of exogenous stimulus still hinder the further application of AuNR@MS. To address these issues, herein, we proposed a glutathione (GSH)-responsive multifunctional AuNR@MS nanocarrier with in situ formed silver nanoparticles (AgNPs) as the capping agent. The inner AuNR core functions as a hyperthermia agent, while the outer mesoporous silica shell exhibits the potential to allow a high drug payload, thus posing itself as an effective drug carrier. With the incorporation of targeting aptamers, the constructed nanocarriers show drug release in accordance with an intracellular GSH level with maximum drug release into tumors and minimum systemic release in the blood. Meanwhile, the photothermal effect of the AuNRs upon application to near-infrared (NIR) light led to a rapid rise in the local temperature, resulting in an enhanced cell cytotoxicity. Such a versatile theranostic system as AuNR@MS@AgNPs is expected to have a wide biomedical application and may be particularly useful for cancer therapy.