Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response.
Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response.
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DOI：
10.7554/elife.36209
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发表时间：
2018-03-27
期刊：
影响因子：
7.7
通讯作者：
Hirano T
中科院分区：
文献类型：
--
作者：
Inoshita T;Hirano T
平行纤维（PF）-浦肯野细胞（PC）突触的长时程抑制（LTD）被认为是运动学习的主要细胞机制。然而，LTD对运动学习的必要性受到了LTD缺陷动物正常运动学习的挑战。在这里，我们解决了可能参与的LTD在运动学习中检查LTD是否发生在运动学习中的野生型小鼠。作为运动学习的模型，视动反应（OKR）的适应。OKR是一种抑制动物运动时视觉图像模糊的反射性眼动。OKR在持续视动刺激过程中表现出适应性变化，受小脑小叶的调节。OKR适应后，PF-PC突触的量子兴奋性突触后电流的幅度降低，并且在小叶中LTD的诱导被抑制。这些结果表明，在OKR适应过程中，LTD发生在PF-PC突触。
Long-term depression (LTD) at parallel fiber (PF) to Purkinje cell (PC) synapses has been considered as a main cellular mechanism for motor learning. However, the necessity of LTD for motor learning was challenged by demonstration of normal motor learning in the LTD-defective animals. Here, we addressed possible involvement of LTD in motor learning by examining whether LTD occurs during motor learning in the wild-type mice. As a model of motor learning, adaptation of optokinetic response (OKR) was used. OKR is a type of reflex eye movement to suppress blur of visual image during animal motion. OKR shows adaptive change during continuous optokinetic stimulation, which is regulated by the cerebellar flocculus. After OKR adaptation, amplitudes of quantal excitatory postsynaptic currents at PF-PC synapses were decreased, and induction of LTD was suppressed in the flocculus. These results suggest that LTD occurs at PF-PC synapses during OKR adaptation.