Bcl-2 expression is associated with poor prognosis of solitary plasmacytoma of bone
Bcl-2 expression is associated with poor prognosis of solitary plasmacytoma of bone
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DOI：
10.1007/s00277-013-1897-8
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发表时间：
2014-03-01
影响因子：
3.5
通讯作者：
Zhang, Yizhuo
中科院分区：
文献类型：
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作者：
Guo, Shanqi;Zhi, Yaqin;Zhang, Yizhuo
孤立性骨浆细胞瘤(SPB)是一种罕见的肿瘤，它代表少数以单个溶骨性骨病变为特征的浆细胞局限性恶性肿瘤患者。SPB发病的分子机制至今仍是个谜。信号转导和转录激活因子-3(STAT3)在人类癌症中经常被激活，并与肿瘤的发生有关。本研究应用免疫组织化学方法检测了pSTAT3(STAT3的活性亚型)及其下游调控因子(Bcl2、Bclxl、c-Myc、Cyclin D1、VEGF、CIAP-2、Mcl-1、Survivin)在乳腺癌中的表达，并对其临床特征及相关预后因素进行了分析。Bcl2阳性率为46.7%(14/30)，c-Myc阳性率为36.7%(11/30)，细胞周期蛋白D1阳性率为23.3%(7/30)。单因素分析发现，Bcl2的表达与总生存期和无进展生存期密切相关。Bcl-2和c-Myc阳性表达也是影响多发性骨髓瘤进展时间的一个因素。综上所述，结果表明，Bcl2的表达是SPB患者临床上有意义的预后指标，而结构性激活的STAT3可能不是唯一的主要调节机制。
Solitary plasmacytoma of bone (SPB) is a rare tumor that represents a minority of patients with plasma cell localized malignancy characterized by a single osteolytic bone lesion. The molecular mechanism underlying the genesis of SPB has remained enigmatic. Signal transducers and activators of transcription-3 (STAT3) is often activated in human cancers and is implicated in tumorigenesis. In the present work, the immunohistochemical expression of pSTAT3 (the active isoform of STAT3) and its potential downstream mediators (Bcl-2, Bcl-xL, c-Myc, cyclin D1, VEGF, cIAP-2, Mcl-1, and survivin) were examined, clinical features were investigated, and relative prognostic factors were analyzed. Positive expression of Bcl-2 was observed in 46.7 % (14/30) of patients, c-Myc in 36.7 % (11/30), and cyclin D1 in 23.3 % (7/30). By univariate analysis, Bcl-2 expression was found to be closely associated with shorter overall survival (OS) and progression-free survival. Bcl-2 and c-Myc positive expression were also found to be a factor that affect time to progression to multiple myeloma. In conclusion, results showed Bcl-2 expression to be a clinically significant prognostic indicator for SPB patients and constitutive activated STAT3 may not be the sole primary regulatory mechanism.